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EC number: 481-730-0 | CAS number: 848301-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- (see "Principles of method if other than guideline")
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Naphtha (petroleum), light alkylate
- EC Number:
- 265-068-8
- EC Name:
- Naphtha (petroleum), light alkylate
- Cas Number:
- 64741-66-8
- IUPAC Name:
- Naphtha (petroleum), light alkylate
- Details on test material:
- - Name of test material (as cited in study report): Naphtha (petroleum), light alkylate [CAS 64741-66-8]
- Test substance is closely related to Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear; it is defined as : 'A complex combination of hydrocarbons produced by the distillation of the reaction products of isobutane with monoolefinic hydrocarbons usually ranging in carbon numbers from C3 through C5. It consists of predominantly branched chain saturated hydrocarbons having carbon numbers predominantly in the range of C7-C10 and boiling in the range 90-160°C (194-320°F).'
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 278,4 - 310,1g; females: 214,2 - 229,1g
- Fasting period before study: no
- Housing: individually in hanging stainless steel wire mesh cages
- Diet (e.g. ad libitum): Purina Certified Laboratory Chow 5002®, ad libitum
- Water (e.g. ad libitum): Tap, ad libitum
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71-74
- Humidity (%): 44-56
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle, artificial light
IN-LIFE DATES:
- Males: from 23 April, 1986 to 26 June, 1986 (date of exposure)
- Females: from 20 April, 1986 to 26 June, 1986 (date of exposure)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: none
- Details on inhalation exposure:
- Chamber Operations and Test Substance Administration:
Exposure of the test animals was conducted in a 250 liter stainless steel and glass chamber. The chamber is constructed with a square cross-sectioned area and pyramidal top and base. It was operated in a dynamic mode, with total airflow through the chamber of 2.2 cubic feet per minute (cfm) as measured by a calibrated orifice gauge.
Test material was used as received and was generated as a vapor in the breathing zone of the animals. NAPHTHA (PETROLEUM), LIGHT ALKYLATE was introduced at a rate of 0.34 to 0.51 ml/minute into the top of a vertical counter current heated column. The column was packed with Propac steel mesh and heated by circulation of water from a heated waterbath (74 to 75°C) around the steel mesh. Prewarmed nitrogen gas was introduced at the bottom of the column at a rate of 5.5 to 6.0 liters per minute (1pm). The nitrogen and the NAPHTHA (PETROLEUM), LIGHT ALKYLATE vapours were then mixed with diluting air and introduced into the exposure chamber. Following four hours of exposure, the test material generation system was turned off. Subsequently, air was drawn through the exposure chamber for an additional half-hour period to clear the NAPHTHA (PETROLEUM), LIGHT ALKYLATE vapours. Afterwards, the chamber was opened and the animals were removed.
Atmospheric Sampling:
The exposure chamber atmosphere was recirculated (undiluted) through a Miran 980 infrared (IR) analyzer. Commencing at five minutes after the start of test material generation and at intervals of five to fifteen minutes thereafter, the test atmosphere was analyzed by its IR absorption at 3.393 microns. The atmospheric concentration of NAPHTHA (PETROLEUM), LIGHT ALKYLATE was determined by comparison of absorbance with a standard curve which was prepared with known concentrations of NAPHTHA (PETROLEUM), LIGHT ALKYLATE.
Chamber temperature and relative humidity were monitored continuously during the exposure. Readings were recorded at one-hour intervals. During each hour of the exposure, the test atmosphere was also analyzed gravimetrically and visually (by flashlight) for the presence of any NAPHTHA (PETROLEUM), LIGHT ALKYLATE aerosol. Gravimetric measurement of the test material aerosol concentration was accomplished by drawing a calibrated volume of test atmosphere through a preweighed 25 mm Gelman glass fiber (Type A/E) filter. The aerosol concentration, if any, in the drawn volume was determined by dividing the difference in filter weight by the sample volume.
Appropriate components of the generation system and test material container were weighed before and after the exposure to determine the quantity of test material consumed. This quantity, when divided by the total airflow through the chamber, yielded the nominal exposure concentration. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- analytical: 5040 mg/m³
- No. of animals per sex per dose:
- 5 male and 5 female/dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations every 15 minutes during the first hour of exposure, hourly thereafter until completion of exposure. Post-Exposure (Test Days 2-15): for mortality twice daily; detailed physical examination daily. Weighing: One pretest and on Test Days 8 and 15 (Post-exposure days 7 and 14).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 040 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No deaths resulted.
- Clinical signs:
- other: Clinical signs were languid behaviour and hunched appearance.
- Body weight:
- No treatment-related effects.
- Gross pathology:
- No treatment-related effects.
- Other findings:
- Histopathology (lungs only): histopathology evaluation of the lung were considered unremarkable in that no treatment related effects were apparent.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the conditions of this study, the LC50 for acute inhalation exposure to 'Naphtha (petroleum), light alkylate' is > 5040 mg/m³.
- Executive summary:
'Naphtha (petroleum), light alkylate' was administered via individual inhalation chambers for four hours to ten Sprague-Dawley rats at the analytical vapour concentration of 5040 mg/m³ to assess acute inhalation toxicity. Animals were observed for fourteen days following exposure. There were no mortality and the clinical signs observed were languid behaviour and hunched appearance. There were no treatment-related effects observed at necropsy.
Based on the conditions of this study, the LC50 for acute inhalation exposure to 'Naphtha (petroleum), light alkylate' is > 5040 mg/m³.
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