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EC number: 217-157-8 | CAS number: 1758-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Testing conducted according to GLP and to a standard method, details not yet available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
- Author:
- OECD SIDS
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS; UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aminoiminomethanesulphinic acid
- EC Number:
- 217-157-8
- EC Name:
- Aminoiminomethanesulphinic acid
- Cas Number:
- 1758-73-2
- Molecular formula:
- CH4N2O2S
- IUPAC Name:
- aminoiminomethanesulphinic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- 5 male and 5 female Sprague Dawley rats (Him:OFA) were hair-clipped and received 1 day later a dermal dose of 2000 mg formamidine sulfinic acid/kg body weight. Application was achieved by spreading the test substance over an area of approx. 5 x 6 cm and moistening with destilled water. The area was then covered by a cellulose patch for 24 hours.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg FAS/kg bw
- No. of animals per sex per dose:
- female: 5
male: 5 - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- not reported
- Clinical signs:
- other: The only adverse inlife- observation was chromodacryorrhea which occurred maximally 1 day after administration of the compound in all males and 4/5 females. This was attributed to reduced well-being caused by the dressing.
- Gross pathology:
- At necropsy no changes were observed that could unequivocally be attributed to the test compound.
Applicant's summary and conclusion
- Interpretation of results:
- other: inconclusive
- Remarks:
- Criteria used for interpretation of results: EU
- Executive summary:
As result of the dermal toxicity tes in rats it is concluded that the LD50 (dermal) of formamidine sulfinic acid is beyond 2000mg/kg b.w.
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