Poly[oxy[(hydroxymethyl)-1,2-ethanediyl]], .alpha.-dodecyl-.omega.-hydroxy-

Acute Toxicity: dermal

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Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Deviations:

no

Principles of method if other than guideline:

Not applicable

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Any other information on results incl. tables

Table 1: individual bodyweights

Dose (mg/kg)	Sex	Animals	Day 1	Body weight gain	Day 8	Body weight gain	Day 15
2000	Male	01	270	39	309	53	362
		02	248	53	301	65	366
		03	216	43	259	51	310
		04	253	56	309	69	378
		05	247	40	287	50	337
		Mean	247	46	293	58	351
		SD	20	8	21	9	27
2000	Female	06	237	0	237	23	260
		07	244	2	246	8	254
		08	234	12	246	22	268
		09	235	13	248	18	266
		10	249	-2	247	7	254
		Mean	240	5	245	16	260
		SD	6	7	4	8	7

Table 2: cutaneaous reactions

Time	Animals		Cutaneous reactions
	Males	Females
D 2	5/5	5/5	None
D 3	4/5		Discrete erythema
	1/5	2/5	Moderate erythema
		2/5	Severe erythema
		1/5	Moderate erythema, crusts
D 4		2/5	Dryness of the skin,moderate erythema
		3/5	Moderate erythema
	2/5		Dryness of the skin,discrete erythema
	3/5		None
D 5	2/5	1/5	Dryness of the skin
		1/5	Moderate erythema
		3/5	Dryness of the skin,discrete erythema
	3/5		None
D 6	2/5	2/5	Dryness of the skin
	3/5		None
		3/5	Dryness of the skin, discrete erythema
D 7	2/5	4/5	Dryness of the skin
	3/5	1/5	None
D 8 and D 9	1/5		Crusts, dryness of the skin
	4/5	3/5	Dryness of the skin
		2/5	None
D 10 and D 11	5/5	3/5	Dryness of the skin
		2/5	None
D12 to D 15	5/5	5/5	None