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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 1 978
- Bibliographic source:
- TSCATS: OTS 0534840, Doc. ID. 88-920000388, Younger Labs.|for Monsanto Co., 9-11-78
Materials and methods
- Principles of method if other than guideline:
- other: no data
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- phosphorus oxychloride
- IUPAC Name:
- phosphorus oxychloride
- Details on test material:
- no data on purity of the compound
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: undiluted
- Details on dermal exposure:
- Male and female New Zealand albino rabbits were applied the undiluted test substance for 24 hours and were observed for 14 days.
- Duration of exposure:
- 24 hours
- Doses:
- The test substance was applied at dose levels of 398 mg/kg, 631 mg/kg, 1000 mg/kg, and 1580 mg/kg.
- No. of animals per sex per dose:
- 398 mg/kg (1 male), 631 mg/kg (1 female), 1000 mg/kg (1 male, 1 female), and 1580 mg/kg (1 male)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 631 - 1 000 mg/kg bw
- Mortality:
- The male given 1580 mg/kg and the female given 1000 mg/kg died 2 and 4 days after dosing, respectively.
- Clinical signs:
- other: Signs of intoxication included weight loss, increasing weakness, and collapse.
- Gross pathology:
- Gross autopsy revealed lung and liver hyperemia, enlarged gall bladder, kidney discolouration, and gastro-intestinal inflammation. Viscera of the surviving animals appeared normal after 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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