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Diss Factsheets
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EC number: 433-480-9 | CAS number: 623-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: official guideline method, GLP with certificate, good documentation, identity of substance clear but no details on its purity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 433-480-9
- EC Name:
- -
- Cas Number:
- 623-53-0
- Molecular formula:
- C4H8O3
- IUPAC Name:
- ethyl methyl carbonate
- Details on test material:
- description: clear colourless liquid
batch number: 00925
storage conditions: room temperature, in the dark
Remark of the author of this IUCLID dossier concerning the substance identity:
Every page of the copy of the study report contains an annotation referring to the data sharing agreement in place between the licensee that uses this study report and the data owner. In this data sharing agreement the identity of the chemical substance is specified with "Ethyl Methyl Carbonate - EC No. 433-480-9, CAS Nr. 623-53-0".
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- For analytical monitoring, concentration of the substance in the test medium determined after 0 h, 24 h, 48 h, 72 h and 96 h. Determination of fresh media at 0 h and of old media at 96 h. At 24 h, 48 h and 72 h the old and fresh media were measured.
Duplicate samples taken. Stored frozen (- 20 °C) until analysed.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Source: Brow Well Fisheries Ltd, Hebden, near Skipton, Yorkshire, UK
- Received: 4 Dec 2000
- Keeping conditions until study: in-house, in a glass fibre tank with a "single-pass" water renewal system
ACCLIMATION
- Acclimation period: 31 Jan - 12 Feb 2001
- Acclimation conditions (same as test or not): yes
- Type of food/feeding: commercial trout pellets, feeding discontinued ca. 24 h before start of study
- Mortality: zero, 7 d prior to start of study
- Length at study end: mean standard length 5.0 cm (sd = 0.4)
- Weight at study end: mean weight 1.49 g (sd = 0.30)
- Loading rate (based on mean weight): 0.68 g bodyweight/litre
IN TEST:
- No individual identification of fish
- No feeding of fish
- Criteria of death: absence of both respiratory movement and response to physical stimulation
Study design
- Test type:
- other: semi-static: change of test solution at 0 h, 24 h, 48 h, 72 h and 96 h
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- ca. 100 mg/l CaCO3
- Test temperature:
- 14 +/- 1 °C (temperature control and recorded at 0, 24, 48, 72, 96 h)
- pH:
- 7.4 - 7.7 (recorded at 0, 24, 48, 72, 96 h)
- Dissolved oxygen:
- >= 9.0 mg O2/l () (recorded at 0, 24, 48, 72, 96 h)
- Nominal and measured concentrations:
- nominal: 100 mg/l
measured concentration range: 94 - 101 % of the nominal concentration - Details on test conditions:
- TEST SYSTEM
- Test vessel: glas fibre tank with a "single pass" water renewal system. Minimal headspace. No auxiliary aeration during test. Covered and sealed.
- Test water: laboratory tap water dechlorinated (active carbon filter) and softened by addition of water softener (Elga Nimbus 1248D Duplex Water Softener)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks:
- : 20 fish exposed, no mortalities
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- other: sublethal effects and mortalities (none observed, 20 fish)
- Details on results:
- Range finding study, sub-lethal effects: none at all
Range finding study, mortality: none at all
Definitive study, sub-lethal effects: none at all
Definitive study, mortality: none at all
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Test media: Clear, colourless solution throughout duration of the studies.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the range-finding study as well as in the definitive study (20 fish) the LC50 was > 100 mg/L.
Based on these results no classification for acute aquatic toxicity is required according to REGULATION (EC) No 1272/2008 (of 16 Dec 2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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