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Diss Factsheets
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EC number: 246-073-4 | CAS number: 24199-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
- Reference Type:
- other: Recalculation
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: German standard DIN 38412, L11
- GLP compliance:
- no
Test material
- Reference substance name:
- 6-methylhept-5-en-2-one
- EC Number:
- 203-816-7
- EC Name:
- 6-methylhept-5-en-2-one
- Cas Number:
- 110-93-0
- IUPAC Name:
- 6-methylhept-5-en-2-one
- Details on test material:
- - Name of test material (as cited in study report): Methylheptenon
water solubility: 3.02 g/L
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Test organism: the waterflea Daphnia magna STRAUS was used
- Housing: 30 animals were kept together in 5 l glass beaker containing 2.1 l water at 21°C. The water was exchanged daily and a conductivity of 658 µS/cm, a Ca: Mg ratio of 5:1 and a Na:K ratio of 20:1 were measured.
- The animals showed a reproduction rate of three animals per day.
- Feeding: the animals were fed with the algae Scenedesmus subspicatus once a day.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 21 °C
- pH:
- 7.56 - 7.63
- Dissolved oxygen:
- 8.2 - 8.6 mg/l
- Nominal and measured concentrations:
- Nominal test concentrations of (mg/l):
58, 100, 180, 320, 580 and control - Details on test conditions:
- TEST CONDITIONS
The test conditions corresponded to that in the stock culture.
TEST SYSTEM
- 4x5 daphnids were used per concentration at a total test volume of 20 ml each.
- The test substance was added to the test water without any prior treatment. Subsequently, the daphnids were added to the water.
- As control test water without test substance was used.
- The several treatments were prepared according to the standard guideline and therefore, no measurements of oxygen, pH and temperature at the beginning of the exposure (0h) were performed. After 48h of exposure these parameters were determined: - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 74 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: effective concentration due to volatilisation
- Details on results:
- 48 h EC0 58 mg/L (nominal) based on test material
48 h EC100 320 mg/L (nominal) based on test material
Due to a moderate volatility in an experiment using 100 mg and 200 mg of 6-methylhept-5-en-2-one, but without test organisms, the evaporation over 48 hours was observed. After 48 h approximately 33 % and 35 % of the test substance were evaporated (geometric mean of of all measured TOC values between 0 h and 48 h), respectively. Therefore, the EC50(48h) can be corrected to be 74 mg/l based on 35 % evaporation. - Reported statistics and error estimates:
- Using the Spearman-Kärber method a EC50 (24h) of 168 mg/l and a EC50 (48h) of 114 mg/l was calculated.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.