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EC number: 213-156-1 | CAS number: 927-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity
Fish:
QSAR models were used to estimate LC50 values because no study with the free base was located. The ECOSAR estimate for acute toxicity to fish was LC50(96 hr)= 35 mg/L for the free base and approx. 200 mg/L for the neutral molecule. The estimate obtained with TEST was 64.3 mg/L. The former was selected as key and the latter as supporting study (GUBDH, 2012).
A valid GLP guideline study with the neutralized is available. The LC50(96 hr) 212 mg/L, with a very steep dose-mortality curve (10% mortality at 180 mg/L, 90% mortality at 250 mg/L). The experimental LC50(96 hr)-value is in good agreement with the ECOSAR estimate. Comparison with the estimate for the free base indicates that the latter is much more toxic, most probably as a result of the high pH-value. An increase of the pH is not to be expected at very low doses in the range of the PNEC.
Aquatic invertebrates:
The 48-h EC50for acute effects on aquatic invertebrates is 29.7 mg/L with the free base (EU method C2;Daphnia magna, BASF AG, 1992).
Algae:
The 72-h ErC50based on growth rate was 9 mg/L (free baseScenedesmus subspicatus(EU method C3, BASF AG, 1991).
Microorganisms:
The key study was conducted with Pseudomonas putida using a national method DIN 38412 Part 8 with a duration of 16 hours. The EC50 (16 hrs) ,based on biomass, was 480 mg/L with the free base. No growth inhibition was seen with the neutralized substance at 125 and 1000 mg/L (BASF AG, 1991).
Further, the respiration of activated industrial sludge was not affected, i.e. the oxygen was 5 to 10% increased in the presence of 400 or 800 mg DMBA/L compared to the controls (BASF AG, 1986).
Endpoint |
Organism group |
Species |
Value [mg/L] |
Reliability |
Remarks |
Source |
96-h LC50 |
Fish |
n.a. |
35.0 |
2 key study |
QSAR ECOSAR |
GUBDH (2012) |
96-h LC50 |
Fish |
Fathead minnow |
64.3 |
2 supp. study |
QSAR |
GUBDH (2012) |
48-h EC50 |
Aquatic invertebrates |
Daphnia magna |
29.7 |
1 key study |
analytically verified concentrations; |
BASF AG (1992) |
72-h ECr50 |
Aquatic algae |
Desmodesmus subspicatus(reported asScenedesmus subspicatus) |
9 |
2 Weight of Evidence |
Free base; inhibition based on growth rate |
BASF AG (1991) |
16-h EC50 |
Microorganisms |
Pseudomonas putida |
480 |
2 key study |
inhibition based on biomass |
BASF AG (1991) |
16-h NOEC |
Microorganisms |
Industrial activated sludge |
1000 |
Supporting study |
Parameter: respiration |
BASF AG (1986) |
N, N-dimethylbutylamine is acutely toxic to fish, aquatic invertebrates, and algae. The toxicity of the neutralize molecule is much less pronounced.
Disturbances of wastewater treatment processes are not to be expected when N, N-dimethylbutylamine is released in appropriate amounts.
Long-term toxicity
Fish:
No valid data are available for the assessment of long-term toxicity to fish.
Aquatic invertebrates:
No long-term result study is available.
Algae:
No long-term result is available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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