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Diss Factsheets
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EC number: 921-820-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-12-11 to 2006-12-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been ispected by the quality unit according to the principles of Good Laboratory Practice.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- No analytical determination of the content of the test item in the test solutions during the test was made.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2007-01-12
Test material
- Reference substance name:
- Montanov L
- IUPAC Name:
- Montanov L
- Details on test material:
- Batch: T63645
Appearence: pearls of wax
Purity: ES>99%
Stability: water 96h
solubility <0.1 mg/L
Production date: 2006-09-08
Expiry date: 2008-03-09
Storage: in a closed vessel, at room temperature (20 +/- 5°C)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Concentrations: 1 / 10 / 100 mg/L
Test solutions
- Vehicle:
- no
- Details on test solutions:
- As the solubility lies below 100mg/L, the water-accomodated fraction was prepared for this test. This was done by weighing the nominal load, adding the corresponding amount of dilution water and shaking vigorously for 24 hours. The resulting solution was filtrated through 0.45 um filters
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Variety: Strauss
Strain: Berlin
Sex: female
Age: between 0 and 24 hours
Origin: Umweltdundesamt Berlin
Arrival of Strain: October 4th 2005
selection of the test item was made following the proposal of the guidelines
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 18.2-19.1°C
- pH:
- 7.4-7.8
- Dissolved oxygen:
- above 9.1 mg/L
- Nominal and measured concentrations:
- 1 / 10 / 100 mg/L
- Details on test conditions:
- Main study
Selection of Daphnia
24 hours before the start of the test, the adult animal were separated from the young. 23 hours later, the newborn daphni, aged between 0 and 23 hours, were sieved from the medium and immediatly placed into a 250 mL beaker containing dilution water. After a settling-in period of 30 minutes, animals which showed no apparent damage were used for the test.
Study performance
Using a glass tube (diameter approx. 8 mm), the daphnia were caught anf lifted from the beaker. They were put on a small sieve, and the medium surrounding the animals was sucked off using absorbent paper. Immediatly after that, the animals were put into the respective solution.
The test vessels were left to stand for 48 hours. After 24 and 48 hours, the immobilised daphnia were counted. Daphnia are considered immobilised if they perform no movements or are only able to move their antennae when the beaker is gently agitated.
The pH concentration of dissolved oxygen in the test vessels were measured at the beginning and at the end of the test.
Experimental condition: Vessels: glass beakers, nominal volume 50 mL, tall shape
Feedong: none
Lighting: none
Temperature: 20 +/- 2°C
Date of performance: December 12th-14th 2006
Treatments: 1 / 10 / 100 mg/L
duration: 48 hours
Observation time: 24 and 48 hours
Replicate: four vessels, each containing 20 mL test solution and five daphnia
control: four vessels, each containing 20 mL dilution water and five daphnia - Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- 24h-EC50 of K2Cr2O7 was determined at 1.4 mg/L, lying with the demanded range og 0.6 -2.1 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 24 h NOEC ca. 100 mg/L
48 h NOEC ca. 100 mg/L
24 h EC50 >= 100 mg/L
48 h EC50 >= 100 mg/L - Executive summary:
Determination of 24h-and 48h EC50i of Montanov L against Daphnia magna Strauss according to OECD 202 resp EU C.3.
This study was performed in order to evaluate the toxic potential of Montanov L towards freshwater, using the species Daphnia magna. Daphnia magna STRAUSS, which belongs to the family of crustacea, was chosen in the guideline as a typical part of zoo-plancton. The study was performed for notification purposes.
The study was conduced in accordance to the following guideline:
OECD guideline for testing of chemicals n°202: Daphnia sp., Acute immobilisation test
EU guideline C.2 Acute toxicity for Daphnia
As the item is poorly soluble, the water accomodated fraction was used for the test. This was done by weighing the nominal load, adding the corresponding amount of dilution water and shaking vigorously for 24 hours. The resulting solution was filtrated through 0.45 um filters.
In the main study, three concentrations of the test item in a grometric series (spaced by factor 10, the highest being 100 mg/L) were used. Twenty daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours, the immobilised daphnia were counted.
No immobilisation was observed in the treatments and in the control. The 24h-EC50i of potassium dichromate was tested in a current reference test. The value was determined as 1.4 mg/L, lying with the demanded range og 0.6 -2.1 mg/L.
the following results could be determined for the test item Montanov L (species Daphnia magna).
24 h NOEC ca. 100 mg/L
48 h NOEC ca. 100 mg/L
24 h EC50 >= 100 mg/L
48 h EC50 >= 100 mg/L
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