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EC number: 275-177-2 | CAS number: 71077-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium p-(3-amino-4-methylbenzamido)benzenesulphonate
- EC Number:
- 275-177-2
- EC Name:
- Sodium p-(3-amino-4-methylbenzamido)benzenesulphonate
- Cas Number:
- 71077-34-4
- Molecular formula:
- C14H14N2O4S.Na
- IUPAC Name:
- sodium 4-[(3-amino-4-methylbenzoyl)amino]benzenesulfonate
Constituent 1
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test substance was weighed into a beaker. Water for dilution was added, the mixture was homogenized using an Ultra-Turrax and it was then poured into the chamber under stirring with a glass rod.
All tested concentrations were present as clear solutions. All test batches were homogeneous. No particulate matter was observed.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Strain: HAMILTON-BUCHANAN
- Source: Corporate Toxicology (Hoechst AG)
- Date of hatching: 07/02/94; 08/18/94
- Delivery date: 09/13/94; 10/06/94
- Feeding during test: twice daily ad libitum
- Food type: Tetra Min, Tetra Werke, Melle (FRG)
- Length: 3.0 +-0.15cm;
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: same as test
- Type and amount of food: Tetra Min, Tetra Werke, Melle (FRG)
- Feeding frequency: twice daily ad libitum
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5 mmol Ca2+/Mg2+ / L
- Test temperature:
- 22+-1 °C
- pH:
- 8.1 - 8.3
- Dissolved oxygen:
- 7.3 - 9.5 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg/L measured: 101 mg/L
- Details on test conditions:
- The study consisted of 2 parts. There were 7 fish in each group. The test concentrations, which were selected on the basis of range-finding tests, were as follows:
Part of study Start Test chamber No. Concentration (mg/L)
1 12/19/1994 1 /3 0/50
2 12/27/1994 10/5 0/ 100
The study was conducted in a static system. The test chambers, which were calibrated to 10 liters, were made of glass (length 30 cm, width 22 cm, height 24
cm) and stood in a water bath made of Hostalit Z® with a Plexiglas viewing panel. The temperature of the water bath was regulated by a thermostat to 22 :!:. 1 °C. The chambers were illuminated from above from 06.00 a.m to 06.00 p.m. The light intensity directly over the chambers was approximately 700 lux.
The test chambers were not aerated during the course of the study. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 is greater than 100 mg/L
- Executive summary:
When testing the lethal effect of the substance in zebra fish (Brachydanio rerio) over a total of 96 hours according to OECD 203, no lethality occurred at 50 and 100 mg/L. The LC50 after 96 hours therefore exceeds 100 mg/L. The fish showed only slight symptoms which were reversible within 24 hours after study start. The concentrations tested were 50 and 100 mg/L and a negative control (0 mg/L).
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