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Diss Factsheets
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EC number: 940-543-9 | CAS number: 354-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test was performed on guinea pig.
The induction phase was a single intradermal injection of substance solutions into ears.
After 11 days, the substance was applied on the shaved skin sections sized 2 x 2 cm to check for hypersensitivity. The reaction was recorded immediately after the substance application and after 24 and 48 hours. - GLP compliance:
- not specified
- Type of study:
- intracutaneous test
Test material
- Reference substance name:
- 1,1,2-trichloro-1,2-difluoroethane
- EC Number:
- 940-543-9
- Cas Number:
- 354-15-4
- Molecular formula:
- C2HCl3F2
- IUPAC Name:
- 1,1,2-trichloro-1,2-difluoroethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): R122
- Molecular formula: CHCIF–ССI2F
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Induction exposure: dilutions 1:250 and 1:500
Challenge exposure: unchanged
Challengeopen allclose all
- Route:
- other: epicutaneous, coverage not reported.
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Induction exposure: dilutions 1:250 and 1:500
Challenge exposure: unchanged
- No. of animals per dose:
- no data
Results and discussion
Any other information on results incl. tables
At the challenge, 1-2 hours after the application of the substances, no visible changes were observed.
After 24 hours, exposure to HFCF 122a caused low-grade hyperemia with dilution ratio 1:250.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Since essential data on the method and results are not reported, the test cannot be interpreted and the results cannot be considered adequate to aim a definite conclusion on the sensitizing properties of the substance.
- Executive summary:
The objective of the research was to study the toxicity of HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds was made and toxicological tests on HFCF 122a and HCFC 132 were performed, includingstudies of skin-absorption, eye irritating and skin sensitizing properties.
The sensitizing properties of the substances were studied on guinea pigs through the method of O.G. Alekseeva and A.I. Petkevich (1972). Substance solutions were injected intradermally into the outer surface of guinea pig ears with dilution ratio 1:250 and 1:500.
After 11 days, spot tests with the substances were performed on the shaved skin sections sized 2 x 2 cm to check for hypersensitivity. The reaction was recorded immediately after the substance application and after 24 and 48 hours.
The study showed that after 1-2 hours after the application of the substances, no visible changes were observed. However, after 24 hours, exposure to HFCF 122a caused low-grade hyperemia with dilution ratio 1:250.
According to the authors, the study suggests that HFCF 122a has mild allergic action. However, the test was not conducted according to the current recognized guidelines and essential data on method and results are not reported. For this reasoning the results cannot be interpreted and they cannot be considered adequate to aim a definitive conclusion on the sensitizing potential of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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