Registration Dossier
Registration Dossier
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EC number: 938-094-9 | CAS number: -
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- A re-examination of the possible teratogenic effects of butylated hydroxytoluene (BHT) and ist effect on the reproductive capacity of the mouse.
- Author:
- Johnson
- Year:
- 1 965
- Bibliographic source:
- Food Cosmet Toxicol. 1965 Sep; 3(3): 371-375.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Reproductive Toxicity (Generation) Study
- Principles of method if other than guideline:
- Reproductive Toxicity (Generation) Study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
- Details on test material:
- data for components
Constituent 1
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Study observed:
At 0.5%: no anophthalmia was observed in F1 generation; some effects on reproductive function
The study authors concluded that under the conditions of the experiment and in the strains of mice employed, BHT was not a teratogenic agent.
NOAEL (developmental) =714 mg/kg bw/day
Applicant's summary and conclusion
- Conclusions:
- Component data
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