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EC number: 692-719-7 | CAS number: 882167-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
4-Chlorpicolinmethylamid HCl is harmful after single oral exposure (LD50 cut-off, rat: 500 mg/kg bw).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- May to June 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- - Application volume: 10 mL/kg bw
- Rationale for the selection of the starting dose:
As described in the flow charts of Annex 2, OECD guideline 423, the starting dose level should be that which is most likely to produce mortality in
some of the dosed animals. Therefore, the limit dose 2000 mg/kg bw was chosen as starting dose. - Doses:
- 2000 mg/kg bw (1st step) and 300 mg/kg bw (2nd step)
- No. of animals per sex per dose:
- 3 females (2000 mg/kg bw) and 6 females (300 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at least once daily (clinical signs, mortality) or once weekly (weight gain)
- Necropsy of survivors performed: yes - Statistics:
- none
- Sex:
- female
- Dose descriptor:
- other: LD50 cut-off
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: acc. to OECD Guideline 423
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: acc. to GHS
- Mortality:
- At the dose 2000 mg/kg bw all 3 females died within 4 hours after treatment. The dose 300 mg/kg bw was tolerated by all 6 females without mortalities.
- Clinical signs:
- other: At 2000 mg/kg bw piloerection, uncoordinated gait, accelerated breathing, aggravate breathing as well as abdominal and lateral position were observed up to 4 hours after treatment in all animals. The dose 300 mg/kg bw showed piloerection, decreased motili
- Gross pathology:
- No gross pathological findings were observed in animals that died during the observation period and at the end of the study.
- Other findings:
- none
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
The acute oral toxicity of 4¿Chlorpicolinmethylamid HCl was harmful with a LD50 of 500 mg/kg bw in rats (cut-off value) according to OECD TG 423. According to EC Regulation 1272/2008 the LD50 of the test item is > 300 - 2000 mg/kg bw (Category 4 of the Globally Harmonized Classification System). At the limit-dose 2000 mg/kg bw all animals died within 4 hours after treatment. The dose 300 mg/kg bw was tolerated by all 6 females without mortalities. At 2000 mg/kg bw piloerection, uncoordinated gait, accelerated breathing, aggravate breathing as well asabdominal and lateral position were observed up to 4 hours after treatment in all animals. The dose 300 mg/kg bw showed piloerection, decreased motility and narrowed palpebral fissure in all animals up to 24 hours after administration. Neither effects on body weight gain nor gross pathological findings were observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- The study is GLP compliant and is of high quality (Klimisch score=1)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity of 4¿Chlorpicolinmethylamid HCl was harmful with a LD50 of 500 mg/kg bw in rats (cut-off value) according to OECD TG 423 (Gillissen, 2013). According to EC Regulation 1272/2008 the LD50 of the test item is > 300 - 2000 mg/kg bw (Category 4 of the Globally Harmonized Classification System). At the limit-dose 2000 mg/kg bw all animals died within 4 hours after treatment. The dose 300 mg/kg bw was tolerated by all 6 females without mortalities. At 2000 mg/kg bw piloerection, uncoordinated gait, accelerated breathing, aggravate breathing as well asabdominal and lateral position were observed up to 4 hours after treatment in all animals. The dose 300 mg/kg bw showed piloerection, decreased motility and narrowed palpebral fissure in all animals up to 24 hours after administration. Neither effects on body weight gain nor gross pathological findings were observed.
Justification for selection of acute toxicity – oral endpoint
Only one study available
Justification for classification or non-classification
Based on the study results (oral LD50 cut-off value: 500 mg/kg bw or LD50 oral: > 300 - 2000 mg/kg bw) a classification with R22 (harmful if swallowed) according to Directive 67/548/EEC or with Acute Toxicity Cat. 4 (H302:harmful if swallowed) according to Regulation (EC) No. 1272/2008 (CLP) is required.
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