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EC number: 700-717-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
MS-Silane is a UVCB comprised of 13 constituents. They are a structurally similar group of silanes with varying levels of carbon, oxygen and chlorine substitution.
Reliable data are available for four of the constituents of MS-Silane. The in vitro and in vivo genetox testing was conducted for the chlorinated form of the compounds and all tests conducted were found to be negative for genetic effects (see Table 1).
Table 1. Available Genetic Toxicity Data for MS-Silane Constituents
Constituent | % in MS- Silane | In vitro Bacterial Test / Result | In vitro Mammalian Gene Mutation Test / Result | In vitro Mammalian Chrom Ab Test / Result | In Vivo Test / Result |
75-78-5 dichloro(dimethyl)silane | 20-35% | OECD 471 / Negative | OECD 476 / Negative | OECD 473 / Negative | Rodent Bone Marrow Cytogenetic Assay / negative |
75-77-4 chlorotrimethylsilane | 0-5% | OECD 471 / Negative | OECD 476 / Negative | OECD 473 / Negative | OECD 475 / Negative |
10026-04-7 tetrachlorosilane | 0-15% | OECD 471 / Negative | OECD 476 / Negative | OECD 473 / Negative | No data |
1450-14-2 hexamethyldisilane | 5-15% | Negative | No data | No data | No data |
In addition, 60 structurally similiar chlorosilanes, including the 13 constituents found in MS-Silane, were evaluated using the OECD QSAR Profilers for DNA binding (OECD and OASIS), protein binding (OECD and OASIS), and mutagenicity/carcinogenicity alerts (Benigni/Bossa). These profilers are used to develop groupings based on structural and mechanistic properties of the target chemicals. No protein or DNA binding was identified nor were there any carcinogenicity or mutagenicity alerts.
Based on the available data, the structural similarity of the other constituents of MS-Silane, and the OECD Profiler results, MS-Silane is not expected to be a genetic toxicant.
Short description of key information:
In vitro (read across to MS-Silane constituents [dichloro(dimethyl)silane, CAS 75-78-5 (20 -35% in MS-Silane); chlorotrimethylsilane, CAS 75-77-4 (0 - 5% in MS-Silane); and tetrachlorosilane, CAS 10026-04-7 (0 - 15% in MS-Silane)]:
- Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation in all strains tested (equivalent to OECD TG 471)
- Cytogenicity in mammalian cells: negative with and without activation (similar to OECD TG 473)
- Mutagenicity in mammalian cells: negative (similar to OECD 476)
In addition, hexamethyldisilane, CAS 1450-14-2 (5 - 15% in MS-Silane) was also found to be negative with and without activation in all strains tested (equivalent to OECD TG 471).
In vivo (read across to MS-Silane constituents [dichloro(dimethyl)silane, CAS 75-78-5 (20 -35% in MS-Silane) and chlorotrimethylsilane, CAS 75-77-4 (0 - 5% in MS-Silane)]:
- Negative in mouse micronucleus test (US EPA guideline test, similar to OECD 474) and in the mammalian bone marrow chrom ab test (similar to OECD 475).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available information for MS-Silane indicates that when four MS-Silane constituents were tested in vitro they did not induce mutations in bacterial or mammalian cells, nor cause chromosome aberrations in mammalian cells. The conclusion reached from in vitro results is confirmed by the negative result obtained when two MS-Silane constituents were tested in vivo. Therefore it is considered that classification for mutagenicity is not required.
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