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Diss Factsheets
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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: via oral route
The LD50 was determined to be 261 mg/kg bw (EHC, 1989).
Acute toxicity: via dermal route
The LD50 was determined to be 1500 mg/kg bw (ECHA disseminated dossier, Joint submission, 2012).
Acute toxicity: via inhalation route
The LC50 of the test substance was as 11 mg/m3 (RIVM, 1989).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from WHO report on chlorophenols (collective views of an international group of experts)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- no
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 261 mg/kg bw
- Based on:
- test mat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 261 mg/kg bw
- Quality of whole database:
- Estimated Klimisch rating: 2
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from review article (report on chlorophenols - systematic review and critical evaluation of relevant data).
- Principles of method if other than guideline:
- The study was conducted before a guideline was available. No further data are on-hand.
- GLP compliance:
- no
- Remarks:
- prior to GLP
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 11 mg/m³ air
- Based on:
- test mat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 11 mg/m³ air
- Quality of whole database:
- Estimated Klimisch rating: 2
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 500 mg/kg bw
Additional information
Acute toxicity
Based on the results of a reliable study performed by NIOSH/USA and listed in EHC (1989), the acute oral lethal dose (LD50) of the test substance in rat is 261 mg/kg bw. The study is equivalent/similar to OECD Guidance 401.
Further results for the test substance are available which also supports the findings presented above (see table).
Result |
Species |
Test substance |
Reference |
LD50 260 -1400 mg/kg bw |
rat |
4-chlorophenol |
RIVM, 1991 |
LD50 1258 mg/kg bw |
rat (male) |
4-chlorophenol |
ECHA Dossier, 2012 |
LD50 988 mg/kg bw |
rat (female) |
4-chlorophenol |
ECHA Dossier, 2012 |
LD50 1422 mg/kg bw |
mouse (male) |
4-chlorophenol |
EHC, 1989 |
LD50 1373 mg/kg bw |
mouse (female) |
4-chlorophenol |
EHC, 1989 |
Concerning acute toxicity studies for dermal exposure in animals available data is listed below:
The acute dermal toxicity of the test substance was examined in a study according to the method of Noakes and Sanderson (Brit. J. Ind. Med. 26, 59, 1969). Wistar rats of (5 m/f) were dermally exposed to a 50% preparation, resulting in a dosage of 1000, 2500 and 5000 mg/kg bw Animals were then observed for mortality and for clinical symptoms of toxicity for 14 days. All animals were subjected to gross necropsy. Nor mortality neither clinical signs of toxicity were observed. No substance-related findings were revealed at necropsy. The LD50 was deemed as > 5000 mg/kg bw (ECHA disseminated dossier, Joint submission, 2012). Furthermore, an acute dermal study was conducted in rats (Gingell et al., 2001). As LD50 a value of 1500 mg/kg bw is reported (ECHA disseminated dossier, Joint submission, 2012).
With regard to acute inhalation toxicity, a weight-of-evidence approach is used to evaluate the test substance. Based on the results of a study performed in 1964 and listed in RIVM (1991), the acute lethal concentration (LC50) of the test substance (4-chlorophenol) in rat is 11 mg/m³ air; no further details are provided (Klimisch rating score: 4). With reference to data of the ECHA disseminated Dossier (2012), the acute lethal concentration (LC50) of the test substance in rat is specified as 750 mg/L air. Further data are not available.
Justification for selection of acute toxicity – inhalation endpoint
Weight of evidence
Justification for selection of acute toxicity – dermal endpoint
Data originated from: ECHA disseminated dossier, Joint submission (2012)
Justification for classification or non-classification
Based on the available results regarded as relevant for acute oral toxicity (LD50 rat = 261 mg/kg bw), acute dermal toxicity (LD50 rat = 1500 mg/kg bw) and acute inhalation toxicity (LC50 11 mg/m³), the test substance is classified as follows:
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008 (CLP). As a result the substance is considered to be classified for acute toxicity under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014 as follows: acute toxicity: cat. 3, H301, toxic if swallowed; cat. 4, H312, harmful in contact with skin; cat. 4, H332, harmful if inhaled.
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is considered to be classified under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG as follows: Xn; R20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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