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Diss Factsheets
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EC number: 205-592-6 | CAS number: 143-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 29 Jan 1974 - 06 Feb 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only two rabbits used. 20 hours exposure.
- Principles of method if other than guideline:
- Method: BASF-Test: Two animals were treated for 1, 5, 15 minutes and for 20 hours using occlusive conditions. An application site was covered with the liquid test substance. The animals were observed 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 and 72 hours from the raw data were taken into account.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-(2-methoxyethoxy)ethoxy)ethanol
- EC Number:
- 203-962-1
- EC Name:
- 2-(2-(2-methoxyethoxy)ethoxy)ethanol
- Cas Number:
- 112-35-6
- IUPAC Name:
- 2-[2-(2-methoxyethoxy)ethoxy]ethanol
- Details on test material:
- Name of test material: 2-(2-(2-methoxyethoxy)ethoxy)ethanol. Test substance No. 88/289
- Physical state: liquid
- Analytical purity: ca. 95%
-Molecular formula C7H16O4
-IUPAC Name 2-[2-(2-methoxyethoxy)ethoxy]ethanol
-Synonyms Ethanol, 2- 2-(2-methoxyethoxy)ethoxy -
-Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]-
-Molecular formula C7H16O4
-Molecular weight range 164.1995
-SMILES notation COCCOCCOCCO
-InChI InChI=1/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 2.63 kg (mean)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 1 min, 5 min, 15 min, 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: no data
REMOVAL OF TEST SUBSTANCE
- Washing (if done including time after start of exposure: After the application times (1, 5 and 15 min) the skin was washed with Lutrol (100%) and Lutrol solution (50%).
SCORING SYSTEM: The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: 20 hours exposure time
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 20 hours exposure time
Any other information on results incl. tables
Mean erythema score after 24, 48 and 72 h (animal1/animal2)
Exposure time |
24h |
48h |
72h |
mean |
|
1min |
0/0 |
0/0 |
0/0 |
0/0 |
|
5min |
0/0 |
0/0 |
0/0 |
0/0 |
|
15min |
0/0 |
0/0 |
0/0 |
0/0 |
|
20h |
1/1 |
0/0 |
0/0 |
0.3/0.3 |
|
|
|
|
|
|
|
At the end of the observation period after 8 days no erythema were found.
Mean edema score after 24, 48 and 72 h (animal1/animal2)
Exposure time |
24h |
48h |
72h |
mean |
|
1min |
0/0 |
0/0 |
0/0 |
0/0 |
|
5min |
0/0 |
0/0 |
0/0 |
0/0 |
|
15min |
0/0 |
0/0 |
0/0 |
0/0 |
|
20h |
0/0 |
0/0 |
0/0 |
0/0 |
|
|
|
|
|
|
At the end of the observation period after 8 days no edema were found. The test subsstance was not irritating.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a well reported skin irritancy study, the test substance 2-(2-(2 methoxyethoxy)ethoxy)ethanol or 2 -(2 -(2 -butoxyethoxy)ethoxy)ethanol, the subject of this dossier) is expected to exhibit very similar toxicity due to its close structural similarity to 2-(2-(2-methoxyethoxy)ethoxy)ethanol was applied under occluded conditions to rabbit skin for exposure periods of up to 20 hours.
The test substance was then washed before observing the animals for a period of up to 8 days. Mild erythema was seen in one of the two test animals but odema was not reported. Effects disappeared within 48 hours. On the basis of these results the substance is not regarded as a skin irritant. - Executive summary:
In a well reported skin irritancy study, the test substance 2-(2-(2methoxyethoxy)ethoxy)ethanol or 2 -(2 -(2 -butoxyethoxy)ethoxy)ethanol, the subject of this dossier) is expected to exhibit very similar toxicity due to its close structural similarity to2-(2-(2-methoxyethoxy)ethoxy)ethanolwas applied under occluded conditions to rabbit skin for exposure periods of up to 20 hours.
The test substance was then washed before observing the animals for a period of up to 8 days. Mild erythema was seen in one of the two test animals but odema was not reported. Effects disappeared within 48 hours. On the basis of these results the substance is not regarded as a skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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