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EC number: 411-070-0 | CAS number: - KY-ET
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 13, 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed similar to BS ISO 13320-1: 1999, OECD 110 and according to GLP principles. Limited information available to verify the composition of the used test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: BS ISO 13320-1: 1999
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Although these guidelines are not mentioned in the report, it is mentioned that the test equipment and method are recognised by OECD guidelines.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- determination of fibre length and diameter distributions
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene
- EC Number:
- 411-070-0
- EC Name:
- A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene
- Molecular formula:
- C23H24N4O2
- IUPAC Name:
- 3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea
- Details on test material:
- - Name of test material (as cited in study report): KY-ET
- Appearance: white powder
- Storage condition of test material: at room temperature in the dark
Constituent 1
Results and discussion
Particle sizeopen allclose all
- Percentile:
- D50
- Remarks on result:
- other: MMAD: not determined(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
- Percentile:
- D50
- Mean:
- 15.37 µm
- St. dev.:
- 3.69
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- 1.437 µm
- Distribution:
- < 10 %
- Remarks on result:
- other: Average of 3 runs
- No.:
- #2
- Size:
- 4.945 µm
- Distribution:
- < 25 %
- Remarks on result:
- other: Average of 3 runs
- No.:
- #3
- Size:
- 15.37 µm
- Distribution:
- < 50 %
- Remarks on result:
- other: Average of 3 runs
- No.:
- #4
- Size:
- 33.95 µm
- Distribution:
- < 75 %
- Remarks on result:
- other: Average of 3 runs
- No.:
- #5
- Size:
- 51.71 µm
- Distribution:
- < 90 %
- Remarks on result:
- other: Average of 3 runs
Any other information on results incl. tables
Optical Microscope Analysis
- Standard visual observation: Sample observed to be a free-flowing, fine, white powder which forms clusters
- Observation at 100 x magnification: The particles appeared to be amorphous crystals of irregular shape.The smallest particle size was approx. 7.5 μm and the largest size was approx. 103 μm. The particle size distribution was approx. 80% < 80 μm and 20% ≥ 80 μm.
- Observation at 400 x magnification: The sample was observed to be made up of single crystalline particles.
Manual sieve analysis
Not used. The sample was analysed as received.
Laser diffraction particle size analysis
- Run 1 failed to meet the Coulter obscuration requirements and is therefore excluded from the results;
|
RUN 2 |
RUN 3 |
RUN 4 |
Average |
Volume % |
100.0 |
100.0 |
100.0 |
100.0 |
Mean (µm) |
12.42 |
12.47 |
10.08 |
11.60 |
Median (µm) |
17.16 |
16.39 |
13.00 |
15.37 |
Mode (µm) |
51.12 |
55.99 |
42.61 |
51.12 |
95% Conf. Limit (µm) |
0.943 -164 |
0.936 -166 |
0.842 -121 |
0.899 -150 |
S.D. |
3.73 |
3.75 |
3.55 |
3.69 |
Applicant's summary and conclusion
- Conclusions:
- According to GLP principles the particle size distribution of the substance was determined using laser diffraction analysis. The median (D50) of the analysed sample was 15.37 µm.
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