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Diss Factsheets
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EC number: 907-658-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance and no data on guidelines requirements compliance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Type of study / information:
- Short communication
- Principles of method if other than guideline:
- Enzyme assays to determine the induction of a disinfectant agent (containing IBA among others) on the liver microsomal mixed-function oxidase system of rats and rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
- EC Number:
- 204-727-6
- EC Name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
- Cas Number:
- 125-12-2
- Molecular formula:
- C12H20O2
- IUPAC Name:
- (1S,2S,4S) 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Isobornylacetate induces the hepatic microsomal mixed-function oxidase system.
- Executive summary:
In this study wasdetermined whether the mixed-function oxidase system of rats and rabbits housed in animal quarters treated with a new deodorizing/disinfectant agent (containing IBA, among others) was affected by this agent.
Male rats were placed in quarters which contained the deodorizing agent for a period ranging from 1 day to a maximum of 14 days. A number of hepatic microsomal parameters were studied after 1,2, 4, 7 and 14 days of treatment.
The control groups were housed in different animal rooms in the absence of the deodorizing agent.
No deaths were observed throughout the periods of exposure. All parameters were increased after treatment in rats, but not in rabbits. To determine which volatile component of thedeodorizing/disinfectant agent was enhancing the content of cytochrome P450 and the activities of NADPH cytochrome reductase and N-demethylase, various concentrations of alpha-terpineol or isobornyl acetate were injectedintraperitoneally for 3 days.Control groups were injected with isotonic solution of NaCl. The100 mg dose of isobornyl acetate per 100 g of body weight caused a 2.5-fold increase in cytochrome P-450 content, a 2.6 -fold increase in both N-demethylase activities and a 2.0 -fold increase in NADPH cytochrome c reductase activity.Based on these results, isobornylacetate induces the hepatic microsomal mixed-function oxidase system, therefore it is important the environmental control in which experimental animals are housed.
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