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Diss Factsheets
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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is a publication result with a scientific method.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: a modified DIN 38412-L34 protocol (1991).
- GLP compliance:
- no
Test material
- Reference substance name:
- Sulfapyridine
- EC Number:
- 205-642-7
- EC Name:
- Sulfapyridine
- Cas Number:
- 144-83-2
- Molecular formula:
- C11H11N3O2S
- IUPAC Name:
- 4-amino-N-pyridin-2-ylbenzenesulfonamide
- Details on test material:
- no data
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no data
Test solutions
- Vehicle:
- no
- Details on test solutions:
- To exclude the pH-effect, test substance was prepared as a phosphate-buffered solution (0.02 M, pH 7.0, including 2 % NaCl).
Test organisms
- Test organisms (species):
- Vibrio fisheri
- Details on inoculum:
- no data
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 min
Test conditions
- Hardness:
- no data
- Test temperature:
- 15 °C
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- The test was carried out at least twice. At least four controls (2 % NaCl solution, phosphate-buffered) were used. The test was performed at 15 °C using the thermostat. The luminescence was measured with a luminometer. The freeze-dried bacteria were rehydrated according to the test protocol; then, 500 µL aliquots of the bacteria solution were pre-incubated for 15 min at 15 °C. After the initial luminescence had been measured, 500 µL of the diluted samples were added to the bacteria. The bioluminescence was measured again after an incubation time of 30 min. The relative toxicity of the samples was expressed as a percentage inhibition compared to the controls.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- IC50
- Effect conc.:
- > 50 mg/L
- Conc. based on:
- test mat.
- Remarks on result:
- other: no more data available
- Details on results:
- no data
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- The confidence interval (a = 0.05) of the IC50 value was calculated using the R language. The dose-response curve parameters and plots were obtained using the drift package (version 0.05-92) for the R language and environment for statistical computing (www.r-pro- ject.org) as well as SigmaPlot Version 10.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The IC50 was>50 mg/l based on the inhibition of the marine bacteria Vibrio fischeri.
- Executive summary:
The 30-min standard bioluminescence inhibition assay was carried out according to a modified DIN 38412-L34 protocol (1991). The IC50 was>50 mg/l based on the inhibition of the marine bacteria Vibrio fischeri.
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