Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Piperonylbutoxide
- IUPAC Name:
- Piperonylbutoxide
- Details on test material:
- Piperonyl butoxide (PBO)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight recorded weekly - Statistics:
- Not required
Results and discussion
- Preliminary study:
- No
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- None
- Body weight:
- All animals gained the expected body weight.
- Gross pathology:
- No pathological changes were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- LD50 (oral, rat) exceeded 2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study according to GLP and TG OECD 423 a group of 6 female rats received a single dose of 2000 mg/kg bw neat Piperonylbutoxide by gavage. There were no mortalities and no clinical signs. Body weights were not affected and no pathological changes were observed.
LD50 (rat, oral) exceeded 2000 mg/kg bw.
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