Dichloroisobutylaluminium

Endpoint summary

Description of key information

Testing is not required as the substance is corrosive, pyrophoric and reacts explosively with water

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vitro

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is spontaneously flammable in air or in contact with water or moisture at room temperature

Interpretation of results:

other: Waiver

Conclusions:

Corrosive. Flammable in air at room temperature. Thus, exposure of mammalian species to aluminum alkyls would notgenerate meaningful data, and no skin sensitization studies arerequired for this substance.

Executive summary:

Corrosive. Flammable in air at room temperature. Thus, exposure of mammalian species to aluminum alkyls would notgenerate meaningful data, and no skin sensitization studies arerequired for this substance.

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information:

Corrosive. Flammable in air at room temperature.

Most of the chemistry of organoaluminum compounds can be explained in terms of the Lewis acidity of organoaluminum monomers, directly related to the tendency of the aluminum atom to build up an octet of electrons. Reactions of these substances are explosive. The alkyl aluminums are highly reactive towards oxidizing agents including molecular oxygen, thus, the fast reactions in air.

 

Reactions with Oxygen (air) - this reaction is vigorous and will generally cause the material to ignite resulting in a fire difficult to extinguish.

 

Reactions with Water - this reaction is even more violent than those with oxygen. The reaction causes flammable gases that are easily ignited by the fire already created by the organoaluminum compound with water.

 

Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no skin sensitization studies are required for this substance.

Migrated from Short description of key information:

Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, as step 2 of the assessment of skin sensitization endpoint, in vivo testing for skin sensitization is required. A specific rule for adaptation for an  in vivo skin sensitization test states that the study does not need to be conducted if – the available information indicates that the substance should be classified for skin sensitizatin or corrosivity; or – the substance is a strong acid (pH < 2.0) or base (pH > 11.5); or - the substance is flammable in air at room temperature.    

Aluminum alkyls are highly reactive substances both in air and in contact to water, causing explosive or flammable situations as explained below. They are well known to cause burns to skin and eyes, and are flammable in air and water. Thus, skin sensitization tests are technically not feasible to conduct and are scientifically unjustified.

Justification for classification or non-classification

Corrosive. Flammable in air at room temperature.