2-ethoxyethylamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

03. May 1978 - 12. Jun 1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Principles of method if other than guideline:

BASF-Test: A test group consisting of 5 animals/sex was treated by single dermal application of the test substance. Twenty-four hours prior the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. On the testing day, the dermal applications (1000 or 2000 mg/kg bw) of the test material were made in undiluted form on the exposure sites (ca. 42 cm2) of the rats. After application, the exposure site was covered by wrapping the trunk of the animal with an aluminium foil which was securely taped in place. The test material remained in contact with the skin for 24 hours. After the application time the skin was washed with water/Lutrol (1:1). Observations for mortality, local reactions, and behavioral abnormalities were continued for a total of 14 days following the skin applications.

GLP compliance:

no

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethylamine

EC Number:

203-801-5

EC Name:

2-ethoxyethylamine

Cas Number:

110-76-9

Molecular formula:

C4H11NO

IUPAC Name:

2-ethoxyethylamine

Details on test material:

- Name of test material (as cited in study report): 2-Aethxoyaethylamin

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: male: 204 g (mean), female: 208 g (mean)

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

no data

Doses:

1000, 2000 mg/kg bw

No. of animals per sex per dose:

3

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 000 - 2 000 mg/kg bw

Mortality:

1000 mg/kg bw: no mortalities occured.
2000 mg/kg bw: 3/3 males and 2/3 females died within 24 h.

Clinical signs:

other: 2000 mg/kg bw: irregular respiration, apathy, spastic gait

Gross pathology:

2000 mg/kg bw: heart: dilatation on the right ventricle, congestion; liver coloured as clay.
Sacrificed animals: no abnormalities observed.

Any other information on results incl. tables

Of moderate toxicicty after a short term skin contact.