Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 446-630-3 | CAS number: 181587-01-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 Apr 1998 - 9 Aug 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 94/37/EC, Annex I, §2.6 and 2.7
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 9.2 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.3 - <= 7
- Remarks on result:
- other: Influence of pH= 4.6 - 9 being insignificant
Reference
The impurity profile of the test item recovered from the glass beads examined by HPLC no significant changes were detected in the size or number of peaks observed. The HPLC analysis did not show a significant decrease of the product content (< 3%).
The calibration curve fits over the whole working range from 0.56 – 2.8 g/L (5 calibration levels)
with r²=0.99999 (quadratic fit).
|
Sample |
Volume collected [mL] |
pH |
Concentration [mg/L] |
Run 1:Flow rate 0.5 mL/min (30 mL/h, 20.05°C) |
1 |
1 |
|
9.311 |
2 |
25 |
6.98 |
|
|
3 |
1 |
|
9.288 |
|
4 |
25 |
6.78 |
|
|
5 |
1 |
|
9.251 |
|
6 |
25 |
6.81 |
|
|
7 |
1 |
|
9.251 |
|
8 |
25 |
6.80 |
|
|
9 |
1 |
|
9.230 |
|
10 |
25 |
6.49 |
|
|
11 |
1 |
|
9.229 |
|
12 |
25 |
6.54 |
|
|
13 |
1 |
|
|
|
14 |
25 |
6.39 |
|
|
Mean value samples 1-14 |
9.26 |
|||
Run 2:Flow rate 0.3 mL/min (18 mL/h, T=19.85 °C |
1 |
1 |
|
9.135 |
2 |
25 |
6.75 |
|
|
3 |
1 |
|
9.093 |
|
4 |
25 |
6.67 |
|
|
5 |
1 |
|
9.108 |
|
6 |
25 |
6.32 |
|
|
7 |
1 |
|
9.015 |
|
8 |
25 |
6.57 |
|
|
9 |
1 |
|
9.104 |
|
10 |
25 |
6.61 |
|
|
11 |
1 |
|
9.203 |
|
12 |
25 |
6.43 |
|
|
Mean value samples 1 - 12 |
9.11 |
|||
Description of key information
9.2 mg/L at 20 °C, pH=6.3-7.0
Key value for chemical safety assessment
- Water solubility:
- 9.2 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined using column elution method according to EPA OPPTS 830.7840. The solubility was not studied at different pH values since the substance did not show significant differences of values at three pHs (pH= 4.6 - 9), as determined in the preliminary test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
