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EC number: 272-789-1 | CAS number: 68911-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 10/08/1995 to 24/08/1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented GLP study performed according to OECD Guideline 401.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Fatty acids, tall-oil, reaction products with formaldehyde and (Z)-N-9-octadecenyl-1,3-propanediamine
- EC Number:
- 272-789-1
- EC Name:
- Fatty acids, tall-oil, reaction products with formaldehyde and (Z)-N-9-octadecenyl-1,3-propanediamine
- Cas Number:
- 68911-83-1
- Molecular formula:
- C40H76N2O
- IUPAC Name:
- Fatty acids, tall-oil, reaction products with formaldehyde and (Z)-N-9-octadecenyl-1,3-propanediamine
- Details on test material:
- - Name of test material (as cited in study report): CI-46C
- Substance type: Amber liquid
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Buckshire Corp., Perkasie, PA 18944 (U.S.D.A. License # 23-BL)
- Age at study initiation:
- Weight at study initiation: The weight variation did not exceed +/- 20% of the mean weight for each sex.
- Fasting period before study: One group of ten (5 male & 5 female) albino rats was deprived of food but not water overnight prior to dosing.
- Housing: Stainless steel elevated wire mesh flooring, 5 rats/cage by sex.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: The rats were acclimated to the laboratory for at least 5 days prior to the initiation of the study.
- The females used in the study were nulliparous and non-pregnant.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.1 °C - 23.3°C
- Humidity (%): 66-73%
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The volume of liquid administered did not exceed 2 mL/100 g body weight.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual weights were recorded on the day of dosing, weekly thereafter, and prior to necropsy. Changes in weight were calculated and reported.
- Necropsy of survivors performed: yes The animals were euthanized with carbon dioxide at the conclusion of the observation period. Gross necropsies were performed on all animals which die during the 14-day observation period, as well as those surviving the 14-day observation period.
- Other examinations performed: Animals were observed frequently on the day of dosing. A careful clinical examination was performed at least once each day (7 days/week). On weekdays, a second observation of mortality/moribundity was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived during the 14 day observation period after administration of 2000 mg/kg of the substance
- Clinical signs:
- other: Males: Immediate - All animals appeared to be normal 2 hours - All animals appeared to be normal 4 hours - All animals appeared to be normal Days 1 - 10: All animals appeared to be normal Days 11 - 14: 1/5 animals exhibited audible breathing and 4/5 anim
- Gross pathology:
- Males:
No gross abnormalities were observed in any of the five animals necropsied at the conclusion of the 14-day observation period.
Females:
No gross abnormalities were observed in any of the five animals necropsied at the conclusion of the 14-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance, when administered as supplied to 5 male and 5 female albino rats, appears to have an acute oral LD50 greater than 2000 mg/kg.
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