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EC number: 252-156-6 | CAS number: 34690-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity data are available for fish and invertebrates reporting a 96 h LC50value of 130 mg active acid/L withScopthalamus maximus, and a 96 h EC50value of 110 mg/L withAcartia tonsa.
Short-term toxicity data with freshwater organisms are available with the closely related substance HMDMTP acid (CAS 23605-74-5). An LC50value of 440 mg active acid/L was reported in a 14 day study withOncorhynchus mykiss, while a 48 h EC50value of 570 mg active acid/L was reported withDaphnia magna. It is not possible to exclude that the effects observed with the freshwater invertebrates are due to pH effects. However the results do indicate that the substance is of low short-term toxicity.
Only a disregarded study is available assessing the effects of the registered substance on algal inhibition, however the endpoint has been waived on the basis that the complexing properties of phosphonic acid limit algal nutrient availability.Further testing is also not recommended as the tests will be assessing the toxicity of a nutrient bound phosphonic acid and not the substance itself. For further details see section 7.1.4
Long-term toxicity endpoints have been waived on the basis of the risk characterisation outcome being <1.
Cationic imbalance in organisms
There is evidence from structurally analogous substances that they have the potential to disrupt bioavailable concentrations of metallic cations in the blood of fish and invertebrates (McLaughlin and Fisk, 2010). The likelihood of this occurring is highest in situations where concentrations of available cations in an organism are limiting. This is unlikely in test media for aquatic toxicity tests. The low bioaccumulation potential of the substances is a further factor to consider since the internal concentration of the phosphonic acid in the organism is not expected to be high.
It is not possible to draw from the available data definitive conclusions regarding the significance of this effect for the results of the toxicity tests. However even though short-term and long-term toxicity was observed at high test concentrations in reliable tests it is unlikely that such high concentrations of phosphonic acid substances would be encountered in the environment. Therefore, it appears that even if the occurrence of cationic imbalances in the blood of the test organisms were responsible for the observed effects, then these effects would be unlikely to occur under environmental conditions. It is inappropriate to explore this issue further at this stage.
Justification for read-across between BHMT and HMDTMP:
Data from HMDTMP-H (CAS number 23605-74-5) have been used to fill in gaps where necessary for the registered substance.
BHMT-H (CAS 34690-00-1) hasthree amine centres (five methylphosphonate groups), connected by two hexyl chains.HMDTMP-H (CAS 23605-74-5) has two amine centres (four methylphosphonate groups), connected by a hexyl chain.
As well as being structural analogues, all these phosphonates have consistent chemical properties including high MW (685 and 492 respectively), very low log Kow(≤-4 for BHMT-H and HMDTMP) and are highly soluble in water. The substances generally posses similar physico-chemical properties and are not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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