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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study preceeds current OECD guidelines, however is equivalent to OECD Guideline 405 (Acute Eye Irritation / Corrosion). No GLP, however the study is sufficiently reported and the results unambiguous.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine
EC Number:
223-362-3
EC Name:
N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine
Cas Number:
3855-32-1
Molecular formula:
C11H27N3
IUPAC Name:
(3-{[3-(dimethylamino)propyl](methyl)amino}propyl)dimethylamine
Test material form:
solid - liquid: suspension

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.1ml
Duration of treatment / exposure:
5 minutes exposure with 48-hour observation period
24-hours exposure with 72-hour observation period
Number of animals or in vitro replicates:
2 groups, 8 per group

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 5 minute sexposure
Score:
>= 1 - < 4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Severely damaging to eyes of rabbits.
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24-hour exposure
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Severely damaging to eyes of rabbits.
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 5 minute exposure
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Severely damaging to eyes of rabbits.
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 hour exposure
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Severely damaging to eyes of rabbits.
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 5 minute exposure
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Severely damaging to eyes of rabbits.
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 hour exposure
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Severely damaging to eyes of rabbits.
Irritant / corrosive response data:
The substance is severely damaging to eyes of rabbits, with no recovery after 30-day observation period.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is severely damaging to eyes of rabbits, with no recovery after 30-day observation period. The substance is severely irritating and corrosive to the skin and eyes.