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EC number: 603-894-6 | CAS number: 135108-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 40CFR Part 158 Series 81-2, EPA Pesticide Assessment Guidelines. F 1984
- Deviations:
- no
- Principles of method if other than guideline:
- The test substance was dosed at a level of 1.0 g/kg. A group of animals (5 male 5 female) with healty intact skin was used. The substance was applied to approxinately 10% of the body surface.of each animal. The dressings were removed after 24 hours and observed over a period of 14 days for any sign of toxicity.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-bis[(4-aminocyclohexyl)methyl]aniline; 2,4-bis[(4-aminocyclohexyl)methyl]cyclohexan-1-amine; 2-[(1-aminocyclohexyl)methyl]aniline; 4-[(4-aminocyclohexyl)methyl]cyclohexan-1-amine; 4-{[4-({4-[(4-aminocyclohexyl)methyl]cyclohexyl}amino)cyclohexyl]methyl}cyclohexan-1-amine
- EC Number:
- 603-894-6
- Cas Number:
- 135108-88-2
- Molecular formula:
- Exact identification is not feasible
- IUPAC Name:
- 2,4-bis[(4-aminocyclohexyl)methyl]aniline; 2,4-bis[(4-aminocyclohexyl)methyl]cyclohexan-1-amine; 2-[(1-aminocyclohexyl)methyl]aniline; 4-[(4-aminocyclohexyl)methyl]cyclohexan-1-amine; 4-{[4-({4-[(4-aminocyclohexyl)methyl]cyclohexyl}amino)cyclohexyl]methyl}cyclohexan-1-amine
- Test material form:
- liquid: viscous
- Details on test material:
- The concentration of PACM oligomers (Formaldehyde, polymer with benzenamine, hydrogenated) in isopropanol was 70%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The New Zealand White rabbit, weighing 2.0 to 3.0 kg, was used for this study. The animals were obtained
from Buckshire Corp., Perkasie, PA 18944 (U.S.D.A. License #23-BL).
The animals were individually housed and maintained in accordance with standards set forth in the Guide for
the Care and Use of Laboratory Animals (NIH Publication No. 86-23). The rabbits were acclimated to the
laboratory for at least 5 days prior to dosing.
Temperature: 60°F - 75°F
Relative Humidity: 30-80%
Light: 12 hour light/dark cycle
Diet: Wayne 15% Rabbit Ration and tap water were provided ad libitum. Based on our current
knowledge, no contaminants are known to be in this diet or water which might be expected to
interfere with the objectives of the study.
Caging: Stainless steel elevated wire mesh flooring, 1 rabbit/cage.
The animals were individually identified by an ear tag and each cage was identified with a cage card.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Isopropanol
- Details on dermal exposure:
- The test article was dosed as supplied, at a dose level of 1.0 g/kg
A group of 10 rabbits (5 male & 5 female) with healthy intact skin was used. Approximately 24 hours before
testing, the fur was clipped from the backs of the test animals.
All rabbits were weighed and the correct amount of test article was applied to approximately 10% of the
body surface on each animal. The treated area was covered with a large porous gauze patch and wrapped
with an occlusive material and held in place with an elastic bandage to ensure that the animal did not
ingest the test article. The dressings were removed after 24 hours and any excess material removed, where
practical, using water or an appropriate solvent. - Duration of exposure:
- 24 hours
- Doses:
- 1 g/kg
- No. of animals per sex per dose:
- 5 male
5 female - Control animals:
- no
- Details on study design:
- The animals were observed for a 14 day period, for signs of toxicity (systemic and topical) and for
mortalities. Animals were observed frequently during the first day of dosing, and twice per day (morning
and afternoon) on weekdays. On weekends and holidays, animals were observed once per day.
Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. The
animals were euthanized using T-61@ at the conclusion of the observation period. Gross necropsies were
performed on all animals. - Statistics:
- no data available
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Males: Necrotic skin and severe edema was noted after unwrapping at 24 hours. At 7 days 5/5 animals exhibited necrotic skin and severe edema. At 14 days, 3/5 animals exhibited necrotic skin and severe edema, 1/5 animals exhibited peeling necrotic skin and
- Gross pathology:
- No gross abnormalities were noted for 5/5 males necropsied at the conclusion of the 14 day observation period.
No gross abnormalities were noted for 5/5 females necropsied at the conclusion of the 14 day observation period. - Other findings:
- none
Applicant's summary and conclusion
- Conclusions:
- The acute dermal toxicity of Formaldehyde, polymer with benzenamine, hydrogenated appears to be greater than 700 mg/kg. At this dose level the test material was corrosive to skin but no mortalities occurred.
- Executive summary:
Formaldehyde, polymer with benzenamine, hydrogenated when dosed at a 70% concentration in isopropanol and studied in male and female albino rabbits combined was corrosive to the skin and had an acute dermal LD50 >1000 mg/kg.
The LD50 in male and female rabbits, based on the substance (formaldehyde, polymer with benzenamine, hydrogenated) appears to be >700 mg/kg.
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