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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 448-100-7 | CAS number: 70441-63-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Guidance on Safe Use
Administrative data
First-aid measures
General advice:
Move out of dangerous area. Place and transport victim in stable position (lying sideways). Remove contaminated clothing immediately and dispose of safely.
Inhalation:
Call a physician or poison control center immediately. Move to fresh air. Keep patient warm and at rest.
Skin contact:
Wash off thoroughly with plenty of soap and water, if available with polyethyleneglycol 400, subsequently rinse with water. Call a physician or poison control center immediately.
Eye contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a physician or poison control center immediately.
Ingestion:
Rinse mouth. Do NOT induce vomiting. Call a physician or poison control center immediately. Risk of product entering the lungs on vomiting after ingestion.
Indication of any immediate medical attention and special treatment needed
Risks: Danger of formation of methaemoglobin.
Treatment
Initial treatment: symptomatic. In case of ingestion gastric lavage should be considered in cases of significant ingestions only within the first 2 hours. However, the application of activated charcoal and sodium sulphate is always advisable. In case of methaemoglobinemia, oxygen and specific antidotes (methylene blue/ toluidine blue) should be given. Keep under medical supervision for at least 48 hours.
Fire-fighting measures
5.1 Extinguishing media
Suitable: Water spray, Dry powder, Foam, Carbon dioxide (CO2)
Unsuitable: High volume water jet
5.2 Special hazards arising from the substance or mixture
The product is combustible. Heating containers can lead to increased pressure with risk of explosion., In the event of fire the following may be released: Carbon dioxide (CO2), Carbon monoxide (CO), Nitrogen oxides (NOx), Hydrogen fluoride, Hydrogen cyanide (hydrocyanic acid)
5.3 Advice for firefighters
Special protective equipment for firefighters: In the event of fire and/or explosion do not breathe fumes. In the event of fire, wear self-contained breathing apparatus.
Further information: Contain the spread of the fire-fighting media. Do not allow run-off from fire fighting to enter drains or water courses.
Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Precautions: Use personal protective equipment. Remove all sources of ignition. Ensure adequate ventilation.
6.2 Environmental precautions
Do not allow to get into surface water, drains and ground water.
6.3 Methods and materials for containment and cleaning up
Methods for cleaning up: Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable, closed containers for disposal.
Handling and storage
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
Precautions for safe handling
Advice on safe handling:
Avoid formation of aerosol. Use only in area provided with appropriate exhaust ventilation. Avoid contact with skin, eyes and clothing.
Advice on protection against fire and explosion
Use only in suitably equipped explosive areas using devices suitable for these areas. Keep away from heat and sources of ignition. Take measures to prevent the build up of electrostatic charge.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. When using, do not eat, drink or smoke. Remove soiled clothing immediately and clean thoroughly before using again. Wash hands immediately after work, if necessary take a shower. Keep working clothes separately.
Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers: Keep containers tightly closed in a dry, cool and well-ventilated place. Store in original container. Keep away from direct sunlight.
Advice on common storage: Do not store together with oxidizing agents.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 2810
Shipping information
- Proper shipping name and description:
- TOXIC LIQUID, ORGANIC, N.O.S.
- Chemical name:
- 4-FLUORO-N-ISOPROPYLANILINE
- Language:
- English
- Labels:
- 6.1 + EHS
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- 2810
Shipping information
- Proper shipping name and description:
- TOXIC LIQUID, ORGANIC, N.O.S.
- Chemical name:
- 4-FLUORO-N-ISOPROPYLANILINE
- Language:
- English
- Labels:
- 6.1 + EHS
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 2810
Shipping information
- Proper shipping name and description:
- TOXIC LIQUID, ORGANIC, N.O.S.
- Chemical name:
- 4-FLUORO-N-ISOPROPYLANILINE
- Labels:
- 6.1
- Marine pollutant
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 2810
Shipping information
- Proper shipping name and description:
- TOXIC LIQUID, ORGANIC, N.O.S.
- Chemical name:
- 4-FLUORO-N-ISOPROPYLANILINE
- Labels:
- 6.1
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
Exposure controls
Respiratory protection:
Wear respirator with an organic vapours and gas filter mask (protection factor 10) conforming to EN140 type A or equivalent.
Respiratory protection should only be used to control residual risk of short duration activities, when all reasonably practicable steps have been taken to reduce exposure at source e.g. containment and/or local extract ventilation. Always follow respirator manufacturer's instructions regarding wearing and maintenance.
Hand protection:
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time.
Wash gloves when contaminated. Dispose of when contaminated inside, when perforated or when contamination on the outside cannot be removed. Wash hands frequently and always before eating, drinking, smoking or using the toilet.
Material: Nitrile rubber, Rate of permeability > 480 min, Glove thickness > 0,4 mm, Protective index Class 6, Directive Protective gloves complying with EN 374.
Eye protection:
Wear goggles (conforming to EN166, Field of Use = 5 or equivalent).
Skin and body protection
Wear standard coveralls and Category 3 Type 4 suit.
Wear two layers of clothing wherever possible. Polyester/cotton or cotton overalls should be worn under chemical protection suit and should be professionally laundered frequently.
If there is a risk of significant exposure, consider a higher protective type suit. If chemical protection suit is splashed, sprayed or significantly contaminated, decontaminate as far as possible, then carefully remove and dispose of as advised by manufacturer.
General protective measures:
Avoid contact with skin and eyes. If product is handled while not enclosed, and if contact may occur: Complete suit protecting against chemicals
Stability and reactivity
10.1 Reactivity
Thermal decomposition: Stable under normal conditions.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No hazardous reactions when stored and handled according to prescribed instructions.
10.4 Conditions to avoid
Extremes of temperature and direct sunlight. Heat, flames and sparks.
10.5 Incompatible materials
Acids, Bases
Disposal considerations
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
During the whole life cycle of the substance all necessary measures in accordance to art. 18(4) of (EC) 1907/2006 are undertaken. The substance is handled under strictly controlled conditions.
Dispose in accordance with current regulations and, if necessary, after consultation with the site operator and/or with the responsible authority, the product may be taken to a waste disposal site or incineration plant.
Additional information, e.g.:
Waste air from the process is being burnt.
Solvents, mother liquors, solid or aqueous waste is being burnt.
Waste water is recycled or part of waste water treatment with biological sewage plant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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