Registration Dossier
Registration Dossier
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EC number: 619-801-7 | CAS number: 66319-07-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- methyl 5-methyl-4-oxothiolane-3-carboxylate
- EC Number:
- 619-801-7
- Cas Number:
- 66319-07-1
- Molecular formula:
- C7H10O3S
- IUPAC Name:
- methyl 5-methyl-4-oxothiolane-3-carboxylate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 500µl
- Duration of treatment / exposure:
- 4h
- Observation period:
- 72h
- Number of animals:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
Any other information on results incl. tables
There were no signs of systemic toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item was found to have a slight potential for dermal irritation in this study.
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