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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 457-730-1 | CAS number: 41248-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.7
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar HsdCpb:WU
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 2 % Cremophor EL (v/v)
- Details on oral exposure:
- Method of administration:
Gavage - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 50 mg/kg bw/day
Male: 5 animals at 175 mg/kg bw/day
Male: 5 animals at 612 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 50 mg/kg bw/day
Female: 5 animals at 175 mg/kg bw/day
Female: 5 animals at 612 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
Survival was not affected by the treatment. No animals died
during the study.
Clinical observations revealed no treatment-related clinical
findings at 612 mg/kg bw/d and below. There were no
toxicologically significant differences between treated and
control groups in both sexes for food consumption and body
weight. The water intake was statistical significantly
increased for males at >= 175 mg/kg bw/d.
There were no toxicologically significant differences
between treated and control groups in the functional
observational battery, motor and locomotor activity.
Laboratory findings:
Hematology and clinical biochemistry showed no
toxicologically significant differences between treated and
control groups in both sexes up to and including 612 mg/kg
bw/d.
Urinalysis revealed a decrease of pH values in males and an
increased incidence of epithelial cells in both sexes at 612
mg/kg bw/d.
Effects in organs:
There were no changes in organ weights and necropsy that
were considered to be an effect of treatment.
At microscopy diffuse hyperplasia of the urinary bladder
transitional epithelium was observed in animals of both
sexes at 612 mg/kg bw/d. The hyperplasia affected the whole
bladder circumference and was graded most frequently as
slight. Minimal or slight diffuse hyperplasia was also
observed in the transitional epithelium of the urethra in
several animals given the same dose level. Hypertrophy and
vacuolation of the adrenal cortex was detected in one female
at 612 mg/kg bw/d. Because a finding of that type is usually
not known from controls for this single case a treatment
relation could not be excluded.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 175 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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