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EC number: 203-057-1 | CAS number: 102-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 224 mg/L
Additional information
Reliable results from three studies on the acute toxicity of 2 -dibutylaminoethanol (CAS 102 -81 -8) towards fish are available. A 96-h acute toxicity study was performed under static conditions according to German Industrial Standard DIN 38412, part 15, using Leuciscus idus as test species (BASF AG, 1987, report no. 10F0432/865014). The 96 -h LC50 was determined to be 31.6 mg/L (nominal; geometric mean; pH not adjusted). The toxicity was significantly reduced in pH-adjusted test solutions which resulted in an LC50 of 224 mg/L (geometric mean of LC0 = 100 mg/L and LC100 = 500 mg/L). The test concentrations were not analytically verified. However, DBEA proved to be stable in other studies (e.g. see IUCLID Chapters 6.1.3 or 6.1.5); in addition, the stubstance is assumed to be stable due to the substances' water solubility is 4000 mg/L (BASF SE 2012, report no. 11L00536), its moderate vapor pressure (VP = 0.05 hPa @20°C, BASF SE 2012, report no. 11L00536) and its low Henry's Law Constant (HLC = 0.217 Pa m³/mol, calculated with the VP/WS method, BASF SE 2017).
The results were supported by a GLP-study according to OECD 203, performed with Oryzias latipes as test species. The test conditions were semi-static. The guideline OECD 203 advises a pH adjustment if there is a strong change in the pH of the water after addition of the test substance. The pH strongly increased in this test after addition of the test substance (pH of fresh test solutions 10-100 mg/L: pH 8.5-9.8). The pH of the fresh test solutions was outside the recommended pH-range according to OECD 203 (pH 6.0 to 8.5). Therefore it cannot be excluded that the test substance is less toxic after pH-adjustment. Without pH-adjustment, 2-(dibutylamino)ethanol is acutely harmful to fish according to this test. The 96 -h LC50 was determined to be 29.2 mg/L (analytically verified; not pH-adjusted; NITE, 2004).
In another short-term acute toxicity test according to OECD 203, the 96 -h LC50 was determined to be 32 mg/L (nominal; not pH-adjusted) with Oryzias latipes as test species. This test was performed as a ranging-finding test within a bioaccumulation study according to OECD 305 and GLP (NITE, 2001). The test concentrations were not analytically verified but are assumed to be stable based on the assumptions given above.
The acceptable pH range for fish is given in the OECD TG 203 as pH 6 to 8.5. Without pH-adjustment the pH values exceeded this range; therefore, the data from these tests (BASF AG, 1987, without pH-adjustment; NITE, 2001; NITE, 2004a/2011) with fish should not be considered in the assessment of the DBEA as otherwise pH-effects cannot be distinguished from the inherent toxicity of DBEA to fish.
It is reasonable to conclude that DBEA is with high probability acutely not harmful to fish after pH-adjustment (96-h LC50 = 224 mg/L; BASF AG, 1987).
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