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EC number: 212-084-8 | CAS number: 760-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: FOB segment in full guideline inhalation study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Guideline:
- other: FOB in subchronic inhalation study
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methacrylic acid
- EC Number:
- 201-204-4
- EC Name:
- Methacrylic acid
- Cas Number:
- 79-41-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- 2-methylprop-2-enoic acid
- Details on test material:
- Test substance No.: 06/0581-2
Batch-Identification: 011835eda0
Purity: 99.8 area-%
Homogeneity: Homogeneous
Storage stability: Expiry day: 13 Apr 2008Date of production: 12 Apr 2007
Physical state/Appearance:Liquid / colorless, clear
Storage conditions: Room temperature, no direct sunlight, under light exclusion,
protect against heat, storage between 18-25°C, under atmospheric oxygen
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age when supplied; sex: about 7 weeks, male and female
Supplier: Charles River Laboratories, Research Models and Services, Germany GmbH; Sandhofer Weg 7, 97633 Sulzfeld
During the period when the rats were not exposed they were housed singly in wire cages (type DK III, Becker & Co., Castrop-Rauxel, FRG (floor area about 800 cm²)). Underneath the cages, waste trays were fixed containing bedding material (Type Lignocel FS14 fibres,
dustfree bedding supplied by SSNIFF, Soest, Germany)
The motor activity measurements were conducted in Polycarbonate cages with wire covers from Ehret, Emmendingen, FRG (floor area about 800 cm²) and bedding.
The animals were kept in fully air-conditioned rooms in which a temperature in the range of 20 - 24°C and relative humidity in the range of 30 - 70% were ensured by means of a central air-conditioning system.
A light/dark rhythm of 12 hours was maintained.
The room was completely disinfected using a disinfector ("AUTEX", fully automatic, formalinammonia-based terminal disinfector) before the start of the study. Usually, each week the floor and the walls were cleaned with water containing about 1 % Mikroquat®.
The animals were maintained on milled mouse/rat laboratory diet “GLP”, (Provimi Kliba SA, Kaiseraugst, Basel Switzerland) and tap water ad libitum.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Details on exposure:
- For each concentration, the test substance was supplied to the two-component atomizer of a thermostated vaporizer at a constant rate by means of the piston metering pump. The vapor was generated by spraying the substance with compressed air into a counter current of conditioned supply air (about 50% ± 20% relative humidity, 22°C ± 2°C). Thereafter it was further mixed with conditioned supply air and passed into the inhalation system.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The concentrations of the inhalation atmospheres in test groups 1 - 4 were analyzed by HPLC.
- Duration of treatment / exposure:
- 90 d
- Frequency of treatment:
- 6 hours/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 70 mg/m³ (20 ppm), 141 mg/m³ (40 ppm), 352 mg/m³ (100 ppm ), 1232 mg/m³ (350 ppm )
Basis:
- No. of animals per sex per dose:
- 10/sex/dose
- Control animals:
- yes, sham-exposed
- Details on study design:
- Ten male and ten female Sprague Dawley rats per test group were whole body exposed to a vapor of the test substance on 6 hours per working day for 90 days (65 exposures). The target concentrations were 20, 40, 100 and 350 ppm (corresponding to 70, 141, 352 and 1232 mg/m3). A concurrent control group was exposed to conditioned air.
Examinations
- Observations and clinical examinations performed and frequency:
- Functional observation battery (FOB) was carried out on the assigned animals once before the exposure period and once against the end of the exposure period. Motor activity was measured on the same day and with the same animals as FOB was performed.
Results and discussion
Results of examinations
- Behaviour (functional findings):
- no effects observed
- Details on results:
- Up to the highest dose tested (350 ppm) there were no effects in the functional observational battery and no effects on motor activity.
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 350 ppm
- Sex:
- male/female
- Basis for effect level:
- other: = 1232 mg/m³
- Remarks on result:
- other:
Any other information on results incl. tables
Up to the highest dose tested (350 ppm) there were no effects in the functional observational battery and no effects on motor activity.
Applicant's summary and conclusion
- Conclusions:
- Up to the highest dose tested (350 ppm) there were no effects in the functional observational battery and no effects on motor activity.
- Executive summary:
Methacrylic acid was tested for subchronic inhalation toxicity. Up to the highest dose tested (350 ppm) there were no effects in the functional observational battery and no effects on motor activity.
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