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EC number: 205-538-1 | CAS number: 142-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD guidelines for acute oral toxicity. Peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of Monosodium L-glutamate in Mice and Rats
- Author:
- Hirofumi Moriyuki
- Year:
- 1 978
- Bibliographic source:
- Pharmacometrics, Volume 15 (3), pages 433-436
Materials and methods
- Principles of method if other than guideline:
- No specific guideline followed.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium hydrogen glutamate
- EC Number:
- 205-538-1
- EC Name:
- Sodium hydrogen glutamate
- Cas Number:
- 142-47-2
- Molecular formula:
- C5H8NNaO4
- IUPAC Name:
- sodium hydrogen 2-aminopentanedioate
- Details on test material:
- - Mono sodium glutamate which was commercially available as a food additive was used in this experiment.
- Substance type: hydrated form.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Age at study initiation: 5 weeks
- Weight at study initiation: 90 to 130 g
- Fasting period before study: 8 hours
- Housing: 5 animals per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 1
- Humidity (%): 50 ± 10
- Air-conditioned: number of air changes unknown
- Photoperiod (hrs dark / hrs light): no data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no data available
- Amount of vehicle (if gavage): no data available
- Justification for choice of vehicle: no data available
- Lot/batch no. (if required): no data available
- Purity: no data available
MAXIMUM DOSE VOLUME APPLIED: 40 ml/kg
DOSAGE PREPARATION (if unusual): the test substance was given as an aqueous solution - Doses:
- Male: 0, 12.0, 13.0, 14.48, 16.0, 17.6, 19.4 and 21.3 g/kg
Female 0, 11.0, 12.3, 13.8, 15.5, 17.4, 19.5 and 21.8 g/kg - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data available
- Necropsy of survivors performed: no
- Other examinations performed: acute toxicicity signs of mono sodium glutamate during 2 hours after dosing
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 17.3 other: g/kg
- 95% CL:
- >= 15.8 - <= 19
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 15.8 other: g/kg
- 95% CL:
- >= 14.3 - <= 17.5
- Mortality:
- Dosage 12.0 and 13.0 g/kg: male 1/10
Dosage 14.48 g/kg: male 3/10
Dosage 15.5 g/kg: female 4/10
Dosage 17.4 g/kg: female 7/10
Dosage 17.6 g/kg: male 4/10
Dosage 19.4 g/kg: male 6/10
Dosage 19.5 g/kg: female 8/10
Dosage 21.3 g/kg: male 9/10
Dosage 21.8 g/kg: female 10/10 - Clinical signs:
- other: Acute toxicicity signs of mono sodium glutamate during 2 hours after dosing: Dosage 11.0-14.6 g/kg: twich, ataxia, sedation, abdominal posture, cyanosis Dosage 16.0-21.8 g/kg: accelerative respiration, head flicking, circling, diarrhea, vomit-like motion
- Gross pathology:
- No significant abnormalities were observed in the gross findings of the visceral organs at the termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 values (g/kg body weight) by oral route represented by male and female rats were 17.3 and 15.8 g/kg bw.
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