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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 416-780-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Emergency measure - Inhalation: Move exposed subject to fresh air. Seek medical assitance in
case of known or possible overexposure to this material, or
with symptoms including chest pain, difficulty with
breathing, loss of conciousness or other adverse effects
which may be delayed. If breating has stopped, start basic
life support and seek immediate medical assistance.
Emergency measure - Eyes: Flush eyes continuosly with water for at least 15 minutes.
Do not use a chemical neutraliser.
Obtain medical assistance if symptoms occur.
Emergency measure - Skin: Remove contaminated clothing and flush extensively with
large amounts of water.
Obtain medical assistance if skin reactions occur.
Do not use a chemical neutraliser.
Emergency measure - Ingestion: In the event of swallowing this material, seek immediate
medical attention.
Fire-fighting measures
Recommended extinguishing agent: Water, carbon dioxide, foam or dry chemical extinguishers
Product arising from burning: Toxic or corrosive gases including oxides of carbon and
nitrogen
Product determined by test: N
Protective equipment: Self contained breathing apparatus and full protective
equipment are recommended for firefighters.
Accidental release measures
Emergency measures in case of spillage: Remove or shut off all sources of ignition.
Carefully scoop up the spillage and place in a suitable,
properly labelled container for recovery or disposal. take
care to avoid excessive dust when cleaning up. If waste
water can be directed in onsite water treatment system, wash
down the spillage area with copious amounts of water.
Handling and storage
Handling: Keep away from heat and ignition sources.
Avoid inhalation, ingestion or contact with the skin.
This material has not been tested for its dust explosion
properties. However, like most organic dusts it is likely to
explode when ignited as a dust cloud. Care should be taken
to avoid dispersion as a dust cloud. All equipment used for
handling this material should be bonded and earthed.
Storage: Keep in tightly closed containers or packages. Avoid
prolonged storage at elevated temperatures (greater than
room temperature 20°C).
Keep away from heat and ignition sources.
Transport information
Shippingopen allclose all
SpecialProvisionsopen allclose all
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Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
Shippingopen allclose all
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
Shippingopen allclose all
Special provisions / remarks
- Remarks:
- Transport code: UN-nr: 1325
Transport: "Flammable solid, nos."
IATA: class 4.1. Packaging group II.
IMDG: klasse 4.1. Packaging group II.
imdg page nr. 4146, no marine pollutant
ADR/RID: klasse 4.1, marginal number 2401
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Stability and reactivity
Danger other than fire: No additional dangers known.
Chemical reaction with water: No chemical reaction with water. Expect formation of a light
acidic solution (pH 4).
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of recovery/recycling: Not applicable, since the substance is fully transformed by
its use as chemical reagent in synthesis and is incorporated
in the final farmaceutical product.
Industry - Possibility of neutralisation: The prevailing dangerous characteristics of the substance is
its flammability. By application of the precautions given in
point A.2.5. the dangers are adequately prevented and
neutralised.
Industry - Possibility of destruction: controlled discharge: Controlled discharge of the substance is not recommended.
The substance should preferably be treated as dangerous
chemical waste and be destroyed by incineration.
Industry - Possibility of destruction - incineration: Destruction by incineration, in an agreed centre for
destruction for industrial waste, is recommended.
Industry - Possibility of destruction - water purification: Unless tests in practice show that the substance is well
degraded in an on-site industrial waste water treatment
installation, the destruction by waste water purification is
not recommended.
Public at large - Possibility of recovery/recycling: Not applicable.
Public at large - Possibility of neutralisation: Not applicable.
Public at large - Possibility of destruction: controlled discharge: Not applicable.
Public at large - Possibility of destruction - incineration: Not applicable.
Public at large - Possibility of destruction - water purification: Not applicable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.