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EC number: 700-957-0 | CAS number: 1141852-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 29 Dec 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP analytical report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-Propanediol, 2-methyl-, reaction products with ethenyltrimethoxysilane
- EC Number:
- 700-957-0
- Cas Number:
- 1141852-17-6
- Molecular formula:
- UVCB
- IUPAC Name:
- 1,3-Propanediol, 2-methyl-, reaction products with ethenyltrimethoxysilane
- Reference substance name:
- Reaction products of trimethoxy(vinyl)silane and 2-methylpropane-1,3-diol (2:5-6)
- IUPAC Name:
- Reaction products of trimethoxy(vinyl)silane and 2-methylpropane-1,3-diol (2:5-6)
- Details on test material:
- - Name of test material (as cited in study report): Y-15866
- Physical state: liquid
- Lot/batch No.: 3710-10
- Storage condition of test material: at room temperature about 20 °C
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
In the study C76471, Harlan Laboratories was supposed to develop a method to analyze the test item Y-15866 in test water. To conduct the analytical part of an ecotox study, a sensitive and accurate method is needed. The test item Y-15866 is highly unstable in water (see Harlan study C76302, Y-15866: Determination of the Water Solubility) (Weissenfeld, 2010). This makes it very difficult to develop an analytical method to analyze Y-15866 in water samples. According to the sponsor’s information, most of the Y-15866’s degradation products (i.e. the silanols) are unstable in water, too. They are polymerizing forward and the resulting polymers seem to precipitate. The exception is the degradation product 2-methyl-1,3-propanediol (MPD). This could be analyzed by the sponsor’s gas chromatography method for the neat substance. However, due to the presence of MPD in the test item it would not be possible to distinguish between intrinsic MPD and produced MPD, since the content of MPD in Y-15866 is unknown. The Water Accommodated Fraction (WAF) samples from pre-experiments using an LC-MS/MS method were analysed. However, neither traces of the cyclic monomer (m/z=233) nor of the bridged dimer (m/z= 375) could be detected above LOQ of 0.1 µg/mL. Thus, for quantification of the test item in the ecotox tests the sensitivity of this method was not sufficient. Thus, no appropriate substance specific analytical method could be set up for Y-15866. For the non-specific determination of the Y-15866, measurement of silicon (Si) by atomic absorption spectroscopy or total organic carbon content analysis (TOC-measurements) were discussed. Due to the ubiquitous presence of Silicon, it was decided in accordance with the sponsor to analyze the TOC in the test water samples.
Applicant's summary and conclusion
- Conclusions:
- No suitable substance specific analytical method could be established.
- Executive summary:
In the study C76471, Harlan Laboratories was supposed to develop a method to analyze the test item Y-15866 in test water. To conduct the analytical part of an ecotox study, a sensitive and accurate method is needed. The test item Y-15866 is highly unstable in water (see Harlan study C76302, Y-15866: Determination of the Water Solubility) (Weissenfeld, 2010). This makes it very difficult to develop an analytical method to analyze Y-15866 in water samples. According to the sponsor’s information, most of the Y-15866’s degradation products (i.e. the silanols) are unstable in water, too. They are polymerizing forward and the resulting polymers seem to precipitate. The exception is the degradation product 2-methyl-1,3-propanediol (MPD). This could be analyzed by the sponsor’s gas chromatography method for the neat substance. However, due to the presence of MPD in the test item it would not be possible to distinguish between intrinsic MPD and produced MPD, since the content of MPD in Y-15866 is unknown. The Water Accommodated Fraction (WAF) samples from pre-experiments using an LC-MS/MS method were analysed. However, neither traces of the cyclic monomer (m/z=233) nor of the bridged dimer (m/z= 375) could be detected above LOQ of 0.1 µg/mL. Thus, for quantification of the test item in the ecotox tests the sensitivity of this method was not sufficient. Thus, no appropriate substance specific analytical method could be set up for Y-15866. For the non-specific determination of the Y-15866, measurement of silicon (Si) by atomic absorption spectroscopy or total organic carbon content analysis (TOC-measurements) were discussed. Due to the ubiquitous presence of Silicon, it was decided in accordance with the sponsor to analyze the TOC in the test water samples.
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