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Diss Factsheets
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EC number: 237-198-5 | CAS number: 13684-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- (Q)SAR
- Remarks:
- Estimation using Atkinson method.
- Adequacy of study:
- supporting study
- Study period:
- 1992-06-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR - Atkinson calculation
- GLP compliance:
- no
- Remarks:
- GLP is not relevant for studies using QSAR models to calculate endpoints.
Test material
- Reference substance name:
- Desmedipham
- EC Number:
- 237-198-5
- EC Name:
- Desmedipham
- Cas Number:
- 13684-56-5
- Molecular formula:
- C16 H16 N2 O4
- IUPAC Name:
- ethyl 3´-phenylcarbamoyloxycarbanilate
- Test material form:
- solid: particulate/powder
- Details on test material:
- The test material is Desmedipham but the purity has not been specified.
Constituent 1
Results and discussion
Any other information on results incl. tables
In the case of desmedipham, Kadd does not apply as there are no unsaturated aliphatic groups. Therefore, KOH is given by:
- kabs = 1.44 x 10-12 cm3 molecule-1s-1
- karom 1 = 2.04 x 10-11 cm3 molecule-1s-1; karom 2 = 1.40 x 10-11 cm3 molecule-1s-1; sum = 3.44 x 10-11 cm3 molecule-1s-1
- KOH = (0.144 + 3.44) x 10-11 = 3.58 x 10-11 cm3 molecule-1 s-1.
Using the recommended global 24-h average for the concentration of OH radicals, 5 x 105 molecules/cm3, a first rate constant k can be calculated:
k = KOH x [OH] = 3.58 x 10-11 x 5 x 105 s-1 = 6.44 x 10-2 h-1.
The correct [OH] has been applied for REACH
The corresponding half-life is:
t1/2 = ln2/k = 0.693/6.44 x 10-2 h = 10.75 h.
Applicant's summary and conclusion
- Conclusions:
- Results were presented in the Review Report for Desmedipham (SANCO/4061/2001-Final, 13 February 2004).
- Executive summary:
The photochemical degradation of desmedipham in the atmosphere was estimated with the Atkinson method. Reaction with photochemically generated OH radicals can be expected to be the main phototransformation process for desmedipham in the atmosphere. The bimolecular OH radical rate constant was estimated according the incremental method of Atkinson to be > 3.58 x 10-11 cm3 molecule-1s-1. Assuming the global 24-hour average for the concentration of OH radicals to be 5 x 105 molecules/cm3, this value corresponds to a maximum half-life of 10.8 h for the photochemical-oxidative degradation of desmedipham in air.
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