1-[2-[2-methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde

Explosiveness

Administrative data

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021-06-17 to 2021-06-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2021

Report date:

2021

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

1-[2-[2-methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde

Cas Number:

1903010-39-8

Molecular formula:

C25H23N7O5

IUPAC Name:

1-[2-[2-methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde

Test material form:

solid: particulate/powder

Details on test material:

- Physical state: solid
- Appearance: orange powder

Results and discussion

Small-scale preliminary tests

Small-scale preliminary tests 1

Key result

Parameter:

sensitiveness to impact: impact energy (J)

Remarks on result:

not sensitive to impact using an impact energy of 40 J

Remarks:

The test item was observed to exhibit no reaction at 40 J.

Small-scale preliminary tests 2

Key result

Parameter:

sensitiveness to friction: friction load (N)

Remarks on result:

not sensitive to friction using a friction load of 360 N

Remarks:

The test item was observed to exhibit no reaction at 360 N

Small-scale preliminary tests 3

Key result

Parameter:

thermal sensitivity - Koenen test: diameter of the orifice plate

Remarks on result:

not thermal sensitive if heated under defined confinement

Remarks:

The test item did not exhibit an explosion during any of the tests

Any other information on results incl. tables

1. BAM FALLHAMMER: Test Procedure

The test item was placed in the impact device and the 10 kg weight dropped from a height of 40 cm which is equivalent to 40 J. If an "explosion" was observed, the impact energy was reduced to 7.5 J and further tests conducted.

Mass (kg)	Height (m)	Energy (J)	Test number and result* (X / ✓)	Comments
10	0.4	40	1 2 3 4 5 6 X X X X X X	No reaction

* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).

2. BAM FRICTION: Test procedure

Mass (kg)	Load (N)	Test number and result* (X / ✓)	Comments
10	360	1 2 3 4 5 6 X X X X X X	No reaction

* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).

3. KOENEN TUBE: Test procedure

Mass of test item (g)	Orifice Diameter (mm)	Time for First Ignition (s)	Explosion (X✓)*
13.0	6	18	X
13.0	6	15	X
13.0	6	17	X
13.0	2	14	X
13.0	2	14	X
13.0	2	15	X

* ‘✓’ denotes 3 or more fragments.
‘X’ denotes fewer than 3 fragments.

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

BAM FALLHAMMER: The test item of JNJ-73848255-AAA (T003902) was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union.

BAM FRICTION: The test item of JNJ-73848255-AAA (T003902) was observed to exhibit no reaction at 360 N. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union.

KOENEN TUBE: The test item did not exhibit an explosion during any of the tests. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union.