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EC number: 413-920-6 | CAS number: 88949-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The nano and the bulk form of the test substanse are not biodegradable as shown in the ready biodegradability test.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
Biodegradation studies are availabe on the nano (RCC Ltd. 2008) and the bulk form (RCC NOTOX B.V. 1993).
The nano form was tested in a guideline study according to OECD 301B. It was was not biodegradable (<20%) under the test conditions within 28 days. In the toxicity control, containing both the nano form and the reference item sodium benzoate, no inhibitory effect on the biodegradation of the reference item was determined. Thus, the test substance had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration of 20 mg/L. In the procedure controls, average biodegradation of the reference item was 89% by Exposure Day 14, thus confirming suitability of the activated sludge (>60% degradation by Exposure Day 14). By the end of the test (Exposure Day 28), average biodegradation was 99%. Therefore, the nano form ist not readily biodegradable according OECD criteria.
The study using the bulk form was also performed according to OECD guideline 301B. The relative degradation values calculated from the measurements performed during the test period revealed no significant degradation of the substance at both concentrations (< 6% within 28 days). Since the substance was hardly soluble in water, the lack of microbial degradation was a consequence of the limited availability of the substance for micro-organisms.
Furthermore, a QSAR calculation has been conducted (Sun Chemical 2022):
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment (Q)SAR results were used for aerobic biodegradability in water. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
The results of the QSAR calculation support the findings of the biodegradation studies according to OECD guideline 301B. All calculated metabolites are not readily biodegradable according OECD criteria. Therefore, the test substance and its metabolites is defined as P/vP. Nevertheless, it could be shown, that all relevant metabolites in concentration > 0.1% are not bioaccumulative according PBT criteria and the test substance and its metabolites do not to be classified as PBT and vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.