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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-11-11 to 2020-03-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Batch No.: 2019002
- Purity: 98.39 %
- Physical state: white solid
- Storage conditions: Ambient temperature (10–30 °C)
- Expiry date: 2020-10-21
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
The sample was tested as received. No further preliminary treatment such as drying or milling was performed. - Key result
- Water solubility:
- 0.018 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 5.5 - <= 6.1
- Details on results:
- Preliminary test:
Three preliminary tests were carried out with specified amounts of the test item (see table below) and demineralized water. After each addition of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles. The preliminary test showed that the water solubility of the test item was < 10 mg/L. According to the preliminary test the water solubility was determined by the column elution method in the main test.
Main test:
Column elution
102.9 mg of the test item were dissolved in 100 mL acetone using the ultrasonic bath for 3 minutes. For charging the columns in each case 25 mL of the test item solution was added to about 3 g of sea sand and the mixtures were shaken. The solvent was then removed under reduced pressure using a rotary evaporator (40 °C, approx. 30 mbar). The dry residues were placed into the columns of the test apparatus, which have afterwards been filled with water (test temperature: 20 °C; water pH at 23 °C: 5.3).
After a swelling time of 2 h pumps were started to rinse the test item coated sand with demineralized water. At the end of the study it was confirmed that residual test item remained on the columns. The residual test item was eluted with 50 mL acetone.
As blank value demineralized water was tested. No signal was detected in the range of the retention time of the test item. The concentration of the test item was quantified by HPLC.
The water solubility of the test item was below the quantification limit of 43 µg/L by applying analytical method 1. Applying analytical method 2, the water solubility values given in Table 2 and 3 (see box "Any other information on results inlc. tables") resulted for the test item. According to OECD TG 105 the value of two columns with different flows should not differ by more than 30%. Since this criterion has been met in this study, with a relative standard deviation of 13% of both columns, the mean value of the columns of 18 µ/L resulted for the water solubility of the test item. - Conclusions:
- The water solubility of the test item, using the column elution method, is 0.018 mg/L at 20 °C.
- Executive summary:
The water solubility of the test item was determined according to the "column elution method" as described in EU method A.6 and OECD TG 105. The water solubility was found to be 0.018 mg/L at a temperature of 20 °C.
Reference
Table 1: Results preliminary test
Amount of test item / mg |
Total volume of demineralized water/mL |
Appearance of mixture |
16.10 | 100.00 | not dissolved |
11.10 | 500.00 | not dissolved |
4.70 | 500.00 | not dissolved |
Table 2: Column elution method (column 1, approx. 12.5 mL/h)
Fraction no. | V/mL | pH | Resulting water solubility µg/L |
22.00 | 19.00 | 6.00 | 20.54 |
23.00 | 19.00 | 5.90 | 19.90 |
24.00 | 19.00 | 6.10 | 20.71 |
25.00 | 19.00 | 5.90 | 20.01 |
26.00 | 19.00 | 5.90 | 19.43 |
ln column 1 the mean water solubility applying analytical method 2 was found to be 20.1 µg/L.
Table 3: Column eltution method (column 2, approx. 25.0 mL/h)
Fraction no. | V/mL | pH | Resulting water solubility µg/L |
48.00 | 17.50 | 5.80 | 17.32 |
49.00 | 17.50 | 6.00 | 16.51 |
50.00 | 17.50 | 6.00 | 16.18 |
51.00 | 17.50 | 6.00 | 17.19 |
52.00 | 17.50 | 6.10 | 16.81 |
ln column 2 the mean water solubilíty applying analytical method 2 was found to be 16.8 µg/L.
Table 4: Coating check
Amount of testitem used for coating
|
Measured concentration of test item in eluate
|
Amount of test item eluted
|
Analytical method | |
Column 1 (12.5 mL/h) | 25.7 | 0.327 / 0.329 | 16.4 | 1 |
0.327 / 0.328 | 16.4 | 2 | ||
Column 2 (25.0 mL/h) | 0.301 / 0.3001 | 15 | 1 | |
0.300 / 0.300 | 15 | 2 |
The coating check was successful.
Enough test item remained on the columns.
Description of key information
The water solubility of the registered substance was found to be 0.018 mg/L at a temperature of 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.018 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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