Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 443-870-0 | CAS number: 163520-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The toxicity of the test item was investigated in GLP studies with aquatic organisms of different trophic levels (invertebrates, fish, algae and aquatic plants). Due to the hydrolysis of the substance with a DT50 of 2.3 d, the available tests on fish and aquatic invertebrates were performed in flow-through test systems.
Acute toxicity tests (96 h) according to OECD 203 with two freshwater fish species, bluegill sunfish (Lepomis macrochirus) and rainbow trout (Oncorhynchus mykiss), resulted in LC50-values ranging from 0.22 mg/L to 0.34 mg/L (based on analytically verified test concentrations in flow-through systems). An acute toxicity test on freshwater invertebrates (Daphnia magna) (OECD 202) revealed no toxic effect observable at 0.51 mg/L, the maximum solubility of the test substance. Thus, the EC50 (48 h) value for invertebrates is greater than 0.51 mg/L (based on analytically verified test concentrations in flow-through systems).
For freshwater algae (Pseudokirchneriella subcapitata), no toxic effects occurred up to the maximum solubility of the test item in a test following OECD 201. Hence, the EC50 (72 h) value for aquatic algae is greater than 1.26 mg/L. However, it must be taken into account that the test substance fully hydrolysed over the time span of the study since the test was carried out under static conditions.
As an example for higher aquatic plants, duckweed (Lemna gibba) was exposed to the test substance at its maximum solubility of the substance in the test medium in a semi-static test system according to EPA OPP 123 -2. The medium renewal rate was 2 days. No toxic effects were observed under these conditions over a period of 7 days.
A long-term study according to OECD 210 is proposed to assess the long-term effects for chronic toxicity on fish, the most sensitive organism when comparing the available short-term toxicity data.
Additionally, the effect of the test substance on microorganisms (activated sludge) was examined. In this test system, only a moderate inhibitory effect of 12.7% on microbial respiration was observed at a nominal concentration of 1000 mg/L which represents the highest concentration tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.