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Diss Factsheets
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EC number: 248-339-5 | CAS number: 27215-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Supporting study, no GLP, No guideline required.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2013
- Reference Type:
- publication
- Title:
- The Use of Everted Rat Small Intestinal Sacs In Vitro to Estimate Relative Absorption Potential of a Series of Alpha Olefins. Annual Meeting Abstract Supplement, Society of Toxicology, 2015 Abstract no. 1593
- Author:
- Penman M, Powrie RH and Elcombe CR
- Year:
- 2 014
- Bibliographic source:
- Annual Meeting Abstract Supplement, Society of Toxicology, 2015 Abstract no. 1593
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In vitro gut absorption study
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: in vitro gut absorption
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Male Han Wistar rats (approx. 8-12 weeks old) were obtained from Harlan, Bicester, UK.
Administration / exposure
- Route of administration:
- other: gut absorption model
- Vehicle:
- not specified
Results and discussion
- Details on results:
- The C6, C8-C10 (C9 Rich) and C10 molecules were readily absorbed into the intestinal sacs. Marked inter-compound differences were observed, with the amount of absorption generally decreasing with increasing Carbon number. Olefins with 14 carbons and over were either not absorbed or very poorly absorbed (Figure 1).
The results can be explained analyzing the differences between olefins and dietary-derived fatty acids, which derived from the liase-mediated hydrolysis of dietary triglycerides in the small intestine. In fact, the fatty acids contain an ionisable caboxylic acid function. Due to the small intestine pH, a great amount of fatty acids exist in the form of carboxylate anions in the small intestine. Fatty acidIn fact they are absorbed via the intestinal villi and reassembled into triglycerides and/or via a specific fatty acid transporter protein in the membrane. The carboxylic acid functional group is essential in this step. In addition, a considerable fraction of the fatty acids also enter the enterocyte via a specific fatty acid transporter protein in the membrane.The Vitamin K (lipophilic compound) was also tested. Results showed the poor absorption as well as the olefins >12 C.
Applicant's summary and conclusion
- Conclusions:
- Olefins containing C6, C8 -C10 (C9 Rich) and C10 molecules were readily absorbed into the intestinal sacs. Marked inter-compound differences in absorption were observed, with the amount of absorption decreasing profoundly with increasing Carbon number.
- Executive summary:
An in vitro gut absorption study was performed to determine and rank the intestinal absorption potential of a series of alpha-olefins (Table1). Everted sacs were incubated in “Fed-state Simulated Small Intestinal Fluid” saturated with individual olefins. The sac contents were then collected, extracted and analysed for olefin content using gas chromatography with flame ionisation detection. The result of the study showed that the olefins containing C6, C8 -C10 (C9 Rich) and C10 molecules were readily absorbed into the intestinal sacs. Marked inter-compound differences in absorption were observed, with the amount of absorption decreasing profoundly with increasing Carbon number.
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