Registration Dossier
Registration Dossier
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EC number: 236-152-1 | CAS number: 13194-48-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2000-08-02 to 2000-09-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Ethoprophos
- EC Number:
- 236-152-1
- EC Name:
- Ethoprophos
- Cas Number:
- 13194-48-4
- Molecular formula:
- C8H19O2PS2
- IUPAC Name:
- ethyl bis(propylsulfanyl)phosphinate
- Test material form:
- liquid
Constituent 1
- Reference substance name:
- Ethoprophos
- EC Number:
- 236-152-1
- EC Name:
- Ethoprophos
- Cas Number:
- 13194-48-4
- Molecular formula:
- C8H19O2PS2
- IUPAC Name:
- ethyl bis(propylsulfanyl)phosphinate
- Test material form:
- liquid
- Key result
- Water solubility:
- 1.4 g/L
- Temp.:
- 20 °C
- pH:
- >= 4.61 - <= 7.12
- Key result
- Water solubility:
- 1.3 g/L
- Temp.:
- 20 °C
- pH:
- 4
- Key result
- Water solubility:
- 1.3 g/L
- Temp.:
- 20 °C
- pH:
- 9
- Conclusions:
- The solubility of test substances at 20°C was determined by the shake flask method to be:
1.4 g/L (coefficient of variation = 1.9%) in water
1.3 g/L (coefficient of variation = 3.8%) in water buffered to pH 4
1.3 g/L (coefficient of variation = 2.7%) in water buffered to pH 9
There was no influence of pH on the water solubility. - Executive summary:
The water solubility of the test item was determined in an experimental study according to OECD Test Guideline 105 and EU Method A.6. The water solubility was determined at pH 4, pH 9 and in unbuffered water. No influence of the pH or the stirring time could be detected. The water solubility of the test item was determined to be 1.4 g/L in unbuffered aqueous solution at 20 °C.
Reference
Constituent 1
Results and discussion
Water solubilityopen allclose all
Any other information on results incl. tables
Calibration data are presented in Table 1; the calibration line was established linearly with 1/X weighting. Analytical data are presented in Tables 2 to 4 for distilled water, water buffered to pH 4 and water buffered to pH 9 respectively.
Two incubation baths were used and were constant at temperatures of 19.8 °C and 20.0 °C over the test period.
Table 1 - Calibration data
Sequence reference: | WSOL1 |
Slope: | 8424.6 |
Intercept: | 8.40983 |
Correlation: | 0.99991 |
Quality controls at 1.00 mg/L (%): | 101.4 |
100.5 | |
Quality controls at 10.0 mg/L (%): | 103.8 |
103.4 | |
Quality controls at 100 mg/L (%): | 104.1 |
| |
Minimum calibrant cone (mg/L): | 0.804 |
Maximum calibrant cone (mg/L): | 12 |
Table 2 – Solubility Data in Distilled Water
Test ref | Time at 30 °C (h) | pH | Dil. factor | Peak area | Test substance cone (g/L) |
1 | 72 | 6.76 | 50 | 239229.7 | 1.4198 |
2 | 72 | 6.71 | 50 | 244440.7 | 1.4507 |
3 | 48 | 4.61 | 50 | 239474.8 | 1.4212 |
4 | 48 | 4.99 | 50 | 236416.7 | 1.4031 |
5 | 24 | 7.12 | 50 | 231297.7 | 1.3727 |
6 | 24 | 5.77 | 50 | 234209.6 | 1.3900 |
mean (g/L) 1.410
standard deviation (g/L) 0.027
coefficient of variation (%) 1.93
Table 3 - Solubility data in water buffered to a nominal pH of 4
Test ref | Time at 30 °C (h) | pH | Dil. factor | Peak area | Test substance cone (g/L) |
1 | 72 | 4.30 | 50 | 215770.3 | 1.2805 |
2 | 72 | 4.39 | 50 | 210404.0 | 1.2487 |
3 | 48 | 4.39 | 50 | 206575.9 | 1.2260 |
4 | 48 | 4.42 | 50 | 201200.8 | 1.1941 |
5 | 24 | 4.42 | 50 | 224400.5 | 1.3318 |
6 | 24 | 4.41 | 50 | 214845.7 | 1.2751 |
mean (g/L) 1.259
standard deviation (g/L) 0.048
coefficient of variation (%) 3.80
Table 4 - Solubility data in water buffered to a nominal pH of 9
Test ref | Time at 30 °C (h) | pH | Dil. factor | Peak area | Test substance cone (g/L) |
1 | 72 | 8.84 | 50 | 212800.5 | 1.2629 |
2 | 72 | 8.85 | 50 | 219347.0 | 1.3018 |
3 | 48 | 8.87 | 50 | 221916.6 | 1.3170 |
4 | 48 | 8.88 | 50 | 224988.2 | 1.3352 |
5 | 24 | 8.89 | 50 | 214048.5 | 1.2703 |
6 | 24 | 8.89 | 50 | 227494.2 | 1.3501 |
mean (g/L) 1.306
standard deviation (g/L) 0.035
coefficient of variation (%) 2.67
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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