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EC number: 204-442-7 | CAS number: 121-00-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authoritative database
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances"
- Principles of method if other than guideline:
- BCF value of test chemical was determined in fish cyprinus carpio for 6 week on the basis of lipid content
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Purity: 99 %, - Water solubility : 10 ppm
- Radiolabelling:
- not specified
- Details on sampling:
- 2w, 3w, 4w, and 6w ( w= weeks)
- Vehicle:
- yes
- Test organisms (species):
- Cyprinus carpio
- Route of exposure:
- aqueous
- Test type:
- static
- Details on test conditions:
- RANGE-FINDING / PRELIMINARY STUDY - Test concentrations : Test concentrations : TLm(48h) 6.4 ppm(w/v), Rice fish (Oryzias latipes)
Concentration of vehicle: 1st Concentration area: 500 ppb(w/v), 2nd Concentration area: 50 ppb(w/v) - Nominal and measured concentrations:
- Nominal concentrations 1st Concentration area: 100 ppb(w/v), 2nd Concentration area: 10 ppb(w/v)
- Lipid content:
- 3 %
- Remarks on result:
- other: E. G . Bligh and W. J . Dyer, Can. J. Biochem, Physiol., 37, 911 (1959)
- Conc. / dose:
- 0 mg/L
- Type:
- BCF
- Value:
- >= 16 - <= 21 L/kg
- Basis:
- total lipid content
- Time of plateau:
- 6 wk
- Remarks on result:
- other: other details not available
- Conc. / dose:
- 0 mg/L
- Type:
- BCF
- Value:
- >= 8.1 - <= 18 L/kg
- Basis:
- total lipid content
- Time of plateau:
- 6 wk
- Remarks on result:
- other: other details not available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period. Therefore it is concluded that this test chemical is nonbioaccumulative
- Executive summary:
Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio.
Recovery ratio : Test water : 1st concentration area : 90.1 %, 2nd concentration area : 79.6 %, Fish : 92.7 %, - Limit of detection : Fish : 0.
ppm
And Nominal concentrations used in the study as - 1st Concentration area: 0.0001 mg/L, 2nd Concentration area : 0.00001 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 6.4 ppm(w/v), Rice fish (Oryzias latipes).
Thus according to static Fish test the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period.
Therefore it is concluded that this test chemical is nonbioaccumulative
Reference
|
2w |
3w |
4w |
6w |
|
1st Concentration area
|
Test substance concentration (ppb (w/v)) |
97.6 |
96.3 |
95.9 |
97.2 |
Bioconcentration factor L/kg |
17 |
18 |
19 |
19 |
|
18 |
21 |
16 |
16 |
||
2nd Concentration area
|
Test substance concentration (ppb (w/v)) |
9.83 |
9.83 |
9.86 |
10.1 |
Bioconcentration factor L/kg |
(18) |
(16) |
(9.9) |
(17)
|
|
(16) |
(13) |
(8.1) |
(14)
|
Description of key information
The bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period. Therefore it is concluded that this test chemical is nonbioaccumulative
Key value for chemical safety assessment
- BCF (aquatic species):
- 21 L/kg ww
Additional information
Various experimental studies and one prediction study have been conducted to determine bioaccumulation concentartion factor (BCF) of test chemical and their results are summarized below
In first study the Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio.
Recovery ratio : Test water : 1st concentration area : 90.1 %, 2nd concentration area : 79.6 %, Fish : 92.7 %, - Limit of detection : Fish : 0.
ppm And Nominal concentrations used in the study as - 1st Concentration area: 0.0001 mg/L, 2nd Concentration area : 0.00001 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 6.4 ppm(w/v), Rice fish (Oryzias latipes).
Thus according to static Fish test the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period.
Therefore it is concluded that this test chemical is nonbioaccumulative.
Next study was also reviewed from authoritative database in this the BCF value of test chemical was estimated is 57 dimensionless by using log Kow of 3.50 and regression derived equation and it is far less than 2000 so it is concluded that this chemical is non bioaccumulative.
Last study was the prediction done from EPI suite (2018) in this the estimated bioconcentration factor (BCF) for test chemical iwas estimated to be 57.07L/kg wet-wt. This value does not exceed the bioconcentration threshold of 2000. Thus it is concluded that test chemical is not expected to bioaccumulate in the food chain.
On the basis of all the studies mentioned above it is concluded that the BCF value of test chemical is in range of 8.1 to 57 dimensionless. By considering this range BCF value it is concluded that test chemical is non- bioaccumulative in aquatic species.
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