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EC number: 243-094-0 | CAS number: 19473-49-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 5-potassium hydrogen L-glutamate
- EC Number:
- 243-094-0
- EC Name:
- 5-potassium hydrogen L-glutamate
- Cas Number:
- 19473-49-5
- Molecular formula:
- C5H9NO4.K
- IUPAC Name:
- potassium 5-oxido-5-oxo-L-norvaline
- Test material form:
- solid
1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1.82
- Temp.:
- 20 °C
- pH:
- >= 6.53 - <= 6.81
- Details on results:
- Calculated value of decimal logarithm of Test item 1-octanol/water partition coefficient (log Pow) at 20.0 ± 1.0 °C and at pH ranging 6.53 – 6.81 is -1.82 ± 0.09.
Any other information on results incl. tables
Determination of partition coefficient 1-octanol/water at one pH value
The test item stock solution was prepared in water pre-saturated with 1-octanol.The measuredTest itemconcentration in stock solution (water)was5.8746g/kg (5.8746 g/l) – the result is the average value of two determinations. Density of 1-octanol (supplier data) is 0.825 g/l.
Table 9. Calculated values of partition coefficient 1-octanol/water
Vial number |
1 |
2 |
3 |
4 |
5 |
6 |
|
Volume 1-octanol phase/volume of water phase |
1:1 |
1:2 |
2:1 |
||||
Pow= C1-octanol/Cwater |
0.02 |
0.02 |
0.02 |
0.01 |
0.01 |
0.01 |
|
log Pow= Log(C1-octanol/Cwater) |
-1.72 |
-1.74 |
-1.82 |
-1.83 |
-1.90 |
-1.94 |
|
Average log Pow+ standard deviation |
-1.73 ± 0.01 |
-1.82 ± 0.01 |
-1.92 ± 0.03 |
||||
Average log Pow+ standard deviation |
-1.82±0.09 |
Applicant's summary and conclusion
- Conclusions:
- Calculated value of decimal logarithm of Test item 1-octanol/water partition coefficient (log Pow) at 20.0 ± 1.0 °C and at pH ranging 6.53 – 6.81 is -1.82 ± 0.09.
- Executive summary:
The study of thedetermination of partition coefficient 1-octanol/water was carried out according to the method EC A.8. COUNCIL REGULATION (EC) No 440/2008 (Method A.8. Determination of partition coefficient 1-octanol/water; p. 67) which is in conformity with OECD Guideline 107 and concluded in SPO/BS/10/b, edition 6.
Test conditions
Duplicate test vials containing the required accurately measured amounts of the two solvents together with the necessary quantity of the stock solution were prepared for each of the test conditions water volume/1-octanol volume ratio.The test vials were shaken by hand for about 5 minutes.In order to separate the phases, centrifugation of the mixture was carried out in a laboratory centrifuge maintained at (20 ± 1)°C using rate of rotationapproximately3000 rpm during 15 minutes.
Measurement procedure
The concentrations of test item were determined in both phases byHPLCmethod. The total quantity of the test item present in both phases was calculated and compared with the quantity of the substance originally introduced.pH of the aqueous phase before and after the experiment was measured according to SPO/BS/24/t, edition 3.
Calculated value of decimal logarithm of Test item 1-octanol/water partition coefficient (log Pow) at 20.0 ± 1.0 °C and at pH ranging 6.53 – 6.81 is -1.82 ± 0.09.
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