Saccharomyces cerevisiae cell wall, extracted

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 02 November 2011 to 03 January 2012

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

Version / remarks:

Reg. 440/2008

Deviations:

no

GLP compliance:

yes

Contact with:

powdered cellulose

Key result

Sample tested:

reference mixture as specified

Remarks:

20/80%

Parameter:

maximum burning rate

Result:

4.35 mm/s

Remarks on result:

other: The 6 measured values did not differ from the arithmetic mean value for more than 10%

Key result

Sample tested:

test mixture as specified

Remarks:

10/90 %

Parameter:

maximum burning rate

Result:

4.17 mm/s

Remarks on result:

other: The 6 measured values did not differ from the arithmetic mean value for more than 10%

Interpretation of results:

GHS criteria not met

Conclusions:

Since the mixture of the test item with cellulose has a lower burning rate than the reference mixture, the test item, "Saccharomyces cerevisiae cell wall, extracted" is not considered to have oxidising properties under the experimental conditions used.

Executive summary:

The oxidizing properties of "Saccharomyces cerevisiae cell wall, extracted" has been tested according to EU Method A17 (solids) and the GLP.

After being dried, ground and sieved at 0.125 mm, the test item was mixed with cellulose in the proportion 2:1 (test item/cellulose). This mixture forming a small cone was put in contact with a hot flame. The vigour and duration of the reaction was observed in comparison with the behaviour of the reference substance (barium nitrate) mixed with cellulose and subjected to the same conditions. Since an ignition of the mixture test item/cellulose was observed, the main test was performed.

The test item was dried at about 100°C until constant weight was obtained, and then ground and sieved to less than 0.125 mm. The pile of mixtures was made with a mould (250 mm length, height 10 mm, width 20 mm) and the pile is ignited at one end (~1000°C).

The 3 mixtures of the reference item (Barium nitrate)/cellulose, and test item/cellulose, containing from 10 to 90% of reference or test item, which show the highest burning rates were identified and then the measurements were repeated 6 times. The highest value obtained for the reference mixture and for the test item mixture were compared.

Since the mixture of the test item with cellulose has a lower burning rate ( 4.17 mm/s) than the reference mixture (4.35 mm/s), the test item "Saccharomyces cerevisiae cell wall, extracted" is not considered to have oxidising properties under the experimental conditions used.

This oxidizing properties study is classified as acceptable, and satisfies the guideline requirements of the EU method A17

Description of key information

Since the mixture of the test item with cellulose has a lower burning rate than the reference mixture, the test item, "Saccharomyces cerevisiae cell wall, extracted"  is not considered to have oxidising properties under the experimental conditions used.

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Additional information

The oxidizing properties of "Saccharomyces cerevisiae cell wall, extracted" has been tested according to EU Method A17 (solids) and the GLP.

After being dried, ground and sieved at 0.125 mm, the test item was mixed with cellulose in the proportion 2:1 (test item/cellulose). This mixture forming a small cone was put in contact with a hot flame. The vigour and duration of the reaction was observed in comparison with the behaviour of the reference substance (barium nitrate) mixed with cellulose and subjected to the same conditions. Since an ignition of the mixture test item/cellulose was observed, the main test was performed.

The test item was dried at about 100°C until constant weight was obtained, and then ground and sieved to less than 0.125 mm. The pile of mixtures was made with a mould (250 mm length, height 10 mm, width 20 mm) and the pile is ignited at one end (~1000°C).

The 3 mixtures of the reference item (Barium nitrate)/cellulose, and test item/cellulose, containing from 10 to 90% of reference or test item, which show the highest burning rates were identified and then the measurements were repeated 6 times. The highest value ontained for the reference mixture and for the test item mixture were compared.

Since the mixture of the test item with cellulose has a lower burning rate ( 4.17 mm/s) than the reference mixture (4.35 mm/s), the test item "Saccharomyces cerevisiae cell wall, extracted" is not considered to have oxidising properties under the experimental conditions used.

Justification for classification or non-classification

The maximum burning rate obtained with the test item was: 4.17 mm/s for the test item / cellulose mixture 10/90%.

The maximum burning rate obtained with the reference item was: 4.35 mm/s for the reference item / cellulose mixture 20/80%.

The maximum burning rate of test item / cellulose mixture was slower than the maximum burning rate with reference item / cellulose mixture.

The test item was not considered to have oxidizing properties under the experimental conditions used.