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EC number: 201-854-9 | CAS number: 88-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
1-Chloro-2-nitrobenzene, under appropriate conditions of exposure, is absorbed by the body both via the skin and the gastrointestinal tract as well as via the respiratory tract. Rat studies with labelled chemical show that 1-chloro-2-nitrobenzene absorption is 80 % following oral administration and at least 40 % after open dermal application. 0n 11 consecutive days, 65 mg 1- chloro-2-nitrobenzene/kg bw was administered by gavage to adult and to old rats. On d 1, 5, and 9 applied substance was labelled and urine and faeces were collected in the following 96 hours. The adult rats excreted 71-74 % of the dose in the urine and 20-27 % of the dose in the faeces. Excretion rate increased with the duration of treatment. Urinary excretion rate in the old rats consisted 71-85 % of the dose and did not increase with the duration of treatment. The radioactivity level in the tissues were determined 72 hours after d9-treatment and shown to be 5 % of the dose in adult rats and 8 % in the old rats. At very high doses, e.g. 200 mg/kg bw given orally, urinary excretion is delayed and faecal excretion is markedly suppressed. There is evidence to suggest involvement of the enterohepatic cycle, but there are no signs of accumulation of 1-chloro-2-nitrobenzene or one of its metabolites (BG-Chemie 2000, Nomeir et al. 1992). After oral administration of 100 mg 1-chloro-2-nitrobenzene/kg bw to rabbits 42 % of the dose was excreted in the urine as glucuronides, 24 % as sulfates, 7 % as mercapturic acids and 9 % as free 2- chloroaniline. Only 2-Chloroaniline (0.3%) could be detected in the faeces. 48 hours after administration elimination was complete (Bray et al. 1956). In tissue, only a very small fraction of the administered radioactivity is recovered (BG-Chemie 2000). The main metabolic routes for 1-chloro-2-nitrobenzene in the body consist in reduction of the nitro group to an amino group and hydroxylation of the benzene ring. Apart from 2-Chloroaniline, the corresponding nitrophenols and aminophenols are formed, which are excreted as conjugates of glucuronic acid and sulfuric acid. 2-Chloroaniline also appears in the urine and faeces in the unconjugated form (BG-Chemie 2000, Bray et al. 1956, Sabbioni 1994, Rickert and Held 1990). During reduction of the nitro group to the amino group, the hydroxylamine compound is formed as a highly reactive intermediate which has been detected both in vivo in rats, and in vitro (BGChemie 2000, Sabbioni 1994).
References:
BG-Chemie, Toxicological Evaluation: Report No. 73, o-Chlornitrobenzol, 11/2000.
Bray H.G., et al., The metabolism of the monochloronitrobenzenes in the rabbit. Biochem. J. 64, 38-44 (1956).
Nomeir A.A. et al., Effect of dose of the percutaneous absorption of 2- and 4-chloronitrobenzene in rats. Drug Metab. Dispos. 20, 436-439 (1992).
Rickert D.E., S.D. Held, Metabolism of chloronitrobenzenes by isolated hepatocytes. Drug Metab. Dispos. 18, 5-9 (1990).
Sabbioni G., Hemoglobin binding of nitroarenes and quantitative structur-activity relationships. Chem. Res. Toxicol. 7, 267-274 (1994).
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