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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24-31 May 2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately identified, but accuracy is limited by measuring range and extrapolation. Therefore validation applies with restrictions.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
23. Mar. 2006
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Regulation (EC) N°440/2008, as modified by Reg.(EC) No 761/2009
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht (inspected on 29 & 30 November 2010 / signed on 11 April 2011)
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
Storage condition of test material: fridge (2-8°C); away from light and humidity
Key result
Temp.:
25 °C
Vapour pressure:
0.557 Pa

Table 4.6/1: Vapour Pressures (Effusion Method)

 

Experiment No.

T (°C)

T (K)

VP (Pa)

Stand. Dev. (Pa)

RSD (%)

1

30

303.2

9.76 * 10-01

2.43 * 10-02

2.5

2

45

318.2

4.67

2.30 * 10-01

4.9

 

Vapour pressure at two different temperatures was examined. Both temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P):

log (VP) = -4369.1 x (1/T) + 14.4

 

The linear regression gave a correlation coefficient r of - 1, as only two experiments could be performed for the test item.

 

Due to the high vapour pressure of the test item, it evaporated almost completely at 45 °C (at 10-2 Pa).

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 3.13 * 10-01 Pa

Vapour pressure at 25 °C: 5.57 * 10-01 Pa

 

The extrapolated value of 0.557 Pa is consistent with the calculated vapour pressure of 1.15 to 1.45 Pa using the modified Grain-Watson method.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of test item was measured under GLP according to OECD 104 / EU A4 guideline, effusion method with Knudsen cell (weight loss).

Determinations were conducted at 30 and 45°C, with triplicate measurements for each of the four cells.

The vapour pressure at 25°C of the test item was extrapolated from the regression as 0.557 Pa.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.56 Pa
at the temperature of:
25 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Despite restrictions due to technical inaccuracy, it is considered as key study, and the result is retained as key data.