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EC number: 850-698-3 | CAS number: 2387913-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-08-21 to 2019-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 3.1
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not specified
- Conclusions:
- The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method. The weighted average log Kow was 3.1 at 25.0 °C ± 0.2 °C.
- Executive summary:
The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method.
Summary of the results of the HPLC measurements of the reference compounds and the test item:
Sample
no.1)
tR1
[min]
tR2
[min]
tR
[min]
k’
log k’(x)
log POW(y)
0
1.190
1.199
1.195
---
---
---
1
1.895
1.899
1.897
0.587
-0.231
3.42)
2
1.950
1.955
1.953
0.634
-0.198
2.72)
3
2.189
2.196
2.193
0.835
-0.078
3.22)
4
2.564
2.568
2.566
1.147
0.060
4.52)
5
3.016
3.016
3.016
1.524
0.183
4.62)
6
4.318
4.323
4.321
2.616
0.418
6.52)
7
10.295
10.300
10.298
7.618
0.882
7.92)
Test item peaks
tR
[min]
k’
log k’(x)
log POW(y)3)
log POWmean value (rounded)
Weighted average
log Pow
1
1.763
0.475
-0.323
2.483
2.5
3.1
1.764
0.476
-0.322
2.488
2
2.038
0.705
-0.152
3.283
3.3
2.038
0.705
-0.152
3.283
3
2.318
0.940
-0.027
3.867
3.9
2.318
0.940
-0.027
3.867
4
2.822
1.362
0.134
4.620
4.6
2.830
1.368
0.136
4.630
5
6.134
4.133
0.616
6.874
6.9
6.146
4.143
0.617
6.879
1) For the names of the reference compounds see 9.3.
2) Results from the OECD guideline for the testing of chemicals No. 117: „Partition Coefficient (n-octanol/water), HPLC method“ (13 April 2004).
3) Interpolated from linearized function log POW= f(log k’ ) of the calibration data.
The test item was determined by double determination in two independent measurements.
The deviation of the single log POW-values of the test item from the mean value fall within a range of
≤0.1 units as given by the guideline.
Reference
Description of key information
The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method. The weighted average log Kow was 3.1 at 25.0 °C ± 0.2 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.1
- at the temperature of:
- 25 °C
Additional information
The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method. The weighted average log Kow was 3.1 at 25.0 °C ± 0.2 °C.
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