Fatty acids, C16-18, reaction products with ethanolamine

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

>= 6.69 - <= 8.25

Temp.:

20.5 °C

pH:

ca. 8

Details on results:

2 peaks were detected with UV and 2 with RI. The log Pow values range from 6.69 to 8.25 @ 20.5 ± 1 °C.
These results show all detected peaks which have log Pow values greater than 3.0 and are consistent with a material that has the tendency to accumulate in the environment.
The sample was essentially immiscible in 75:25 MeOH:pH8.0 buffer mobile phase.
The sample was essentially immiscible in methanol.
The sample was found to be miscible in DCM which was injected directly onto the column and then run with 90:10 MeOH:H2O mobile phase.
The validity criteria states that the calibration standards (both UV and RI) should have R2 values greater than 0.90 and that the variation between test replicate peaks should be less than or equal to ±0.1 log units. Both these conditions were met for this test.
DCM was also run as a system blank.
Only one example of each of the blank, standard and sample chromatograms have been included in this report.
The temperatures during the test were recorded using the thermometer DT-K next to the column (Min 20.4°C - Max 21.5°C).

Conclusions:

Fatty acids C16 -18, reaction product with ethanolamine was determined to have a Log Kow between 6.69 and 8.25 at 20.5 ± 1 °C based on the properties of its constituents.

Executive summary:

An HPLC method study was performed according to OECD 117 and fatty acids C16 -18, reaction product with ethanolamine was determined to have a Log Kow between 6.69 and 8.25 based on the properties of its constituents.

Description of key information

An HPLC method study was performed according to OECD 117 and fatty acids C16 -18, reaction product with ethanolamine was determined to have a Log Kow between 6.69 and 8.25 based on the properties of its constituents.

Key value for chemical safety assessment

Log Kow (Log Pow):

8.25

at the temperature of:

20.5 °C