Registration Dossier
Registration Dossier
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EC number: 618-233-7 | CAS number: 890707-28-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8.11.2019 - 17.2.2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 309 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 72 h
- Temp.:
- 29.8 °C
- pH:
- 4
- Key result
- Water solubility:
- 274 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 72 h
- Temp.:
- 29.8 °C
- pH:
- 7
- Key result
- Water solubility:
- 274 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 72 h
- Temp.:
- 29.8 °C
- pH:
- 9
- Conclusions:
- Using the flask method ist was shown that the solubility of 2-amino-5-chloro-N,3-dimethylbenzamide shows pH dependance ranging from 309 mg/L (pH = 4) to 264 mg/L (pH = 9).
- Executive summary:
The objective of this study is to determine the solubility in water of 2-AMINO-5CHLORO-N,3-DIMETHYLBENZAMIDE following the Regulation (EC) No.1907/2006 - and Council regulation (EC) No. 260/2014 - EC A.6. method (2014) and OECD Guideline No. 105 (1995).
The solubility of 2 -AMINO-5 -CHLORO-N,3DIMETHYLBENZAMIDE in water performed at three pH (4, 7 and 9) was as followed:
pH (4) = 309 mg/L
pH(7) = 274 mg/L
pH (9) = 264 mg/L
Reference
Description of key information
The objective of this study was to determine the solubility of 2 -AMINO-5CHLORO-N,3 -DIMETHYLBENZAMIDE
in water following the Regulation (EC) No.1907/2006 - and Council regulation (EC) No. 260/2014 - EC A.6. method (2014) and OECD Guideline No. 105 (1995).
The solubility of 2 -AMINO-5 -CHLORO-N,3DIMETHYLBENZAMIDE in water performed at three pH (4, 7 and 9) is determined to:
pH (4) = 309 mg/L
pH(7) = 274 mg/L
pH (9) = 264 mg/L
Key value for chemical safety assessment
- Water solubility:
- 274 mg/L
- at the temperature of:
- 29.8 °C
Additional information
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