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EC number: 700-363-1 | CAS number: 1335203-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An acute oral toxicity study was carried out according to OECD guideline 420. A group of five female Wistar rats were administered a single oral dose of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes, suspended in distilled water. Neither death nor signs of toxicity were reported during the course of the study.
Acute oral toxicity LD50 > 2000 mg/kg
bw for rat (limit test)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 January 2010 to 4 February 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK limited, Bicester, Oxon, K
- Age at study initiation: 8 to 12 weeks of age
- Weight at study initiation:
- Fasting period before study: Overnight fast prior to dosing and for approximately three to four after dosing
- Housing: Animals were housed in groups of four in suspended solid-floor polypropylene cages.
- Diet (e.g. ad libitum): Ad libitum except during fasting.
- Water (e.g. ad libitum): Free access to drinking water
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25 C
- Humidity (%): 30-70%
- Air changes (per hr): At least 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours dark and 12 hours light
IN-LIFE DATES: From: 19 January 2010 To: 4 February 2010 - Route of administration:
- oral: gavage
- Vehicle:
- other: Suspension in distilled water
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were made at 0.5 hour, 1, 2 and 4 hours after dosing and once daily thereafter. Individual bodyweights were recorded on Day 0, 7 and 14.
- Necropsy of survivors performed: Yes, all animals were subjected to gross necropsy
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Mortality and viability were checked twice daily - Statistics:
- No statistical method was used.
- Preliminary study:
- One animal was chosen as starting dose and administered 2000 mg/kg bw. Since no effects were observed an additional 4 animals were treated with that dose level.
- Key result
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths
- Clinical signs:
- other: No signs of systemic toxicity were noted
- Gross pathology:
- No abnormalities were noted at necropsy
- Other findings:
- No other findings were reported
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the absence of any signs of toxicity, the acute oral median lethal dose (LD50) of the test material in female Wistar rats was estimated to be greater than 2000 mg/kg bw.
- Executive summary:
A group of 5 female Wistar rats was administered a single oral dose of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes suspended in distilled water by gavage at 2000 mg/kg bw. Moratlity was checked twice daily for 14 days. Clinical observations were made at 0.5 hour, 1, 2 and 4 hours after dosing and once daily thereafter. Individual bodyweights were recorded on Day 0, 7 and 14. Gross necropsy was carried out at the end of the study. Neither deaths, signs of systemic toxicity nor abnormalities occurred. All animals gained weight during the study and low increases in bodyweight were not deemed to be treatment related. Teh acute oral median lethal dose (LD50) of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes in females Wistar rat was estimated to be greater than 2000 mg/kg bw. On this basis, Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes does not warrant any classification according to Regulation (EC) No 1272/2008.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Pooles (2010) investigated the potential acute toxic effects of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes to female Wistar rats following exposure by oral gavage. One group of 5 female rats were administered a single dose of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes in suspended distilled water at a dose level of 2000 mg/kg bw. The rats were then observed for 14 days following test article administration. No death occurred during the course of the study. There was no signs of toxicity and all animals gained weight at the end of the study. No abnormalitites were recorded at necropsy. Therefore, the LD50of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes was estimated to be greater than 2000 mg/kg bw.
Justification for classification or non-classification
Based on the absence of any systemic effects in the acute oral study, the LD50 of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes was estimated to be greater than 2000 mg/kg bw. On this basis, Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes does not warrant any classification according to Regulation (EC) No 1272/2008.
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